Results 71 to 80 of about 33,933 (196)

Sales data as a measure of antibiotics usage: Concepts, examples and discussion of influencing factors

Veterinary Medicine and Science, 2020
Monitoring and surveillance of antimicrobial usage in animals is a public health concern and different methods are currently discussed widely in public, science and politics.
Roswitha Merle, Borris Meyer‐Kühling
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Transduction as a Potential Dissemination Mechanism of a Clonal qnrB19-Carrying Plasmid Isolated From Salmonella of Multiple Serotypes and Isolation Sources

Frontiers in Microbiology, 2019
Antimicrobial resistance is an increasing problem worldwide, and Salmonella spp. resistance to quinolone was classified by WHO in the high priority list.
Andrea I. Moreno-Switt, Andrea I. Moreno-Switt, David Pezoa, Vanessa Sepúlveda, Iván González, Dácil Rivera, Patricio Retamal, Paola Navarrete, Paola Navarrete, Angélica Reyes-Jara, Magaly Toro   +10 more
doaj   +1 more source

Antibiotic Exposure in Early Life and Risk of Type 1 Diabetes: A Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Early‐life antibiotic use may increase the risk of childhood type 1 diabetes (T1D), potentially through gut microbiota dysbiosis and associated effects on immune development. This meta‐analysis evaluated associations between early‐life antibiotic use and T1D.
Sharan Ram, Marine Corbin, Andrea ’t Mannetje, Jeroen Douwes, Amanda Kvalsvig, Amanda Eng   +5 more
wiley   +1 more source

Microbiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing

European Journal of Haematology, EarlyView.
ABSTRACT The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.
Rafael Hernani, Eliseo Albert, Carlos Hernani‐Morales, Sheila Zúñiga, Ana Benzaquén, Laura González‐Castillo, Ester Colomer, Júlia Morell, José Francisco Català‐Senent, José Luis Piñana, Estela Giménez, Ariadna Pérez, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Marcos Rivada, Teresa Barber, Teresa Alemany, Enric Santacatalina, Pilar Rentero‐Garrido, María José Terol, Rafael Díaz, David Navarro, Carlos Solano   +22 more
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Recent Advances in the Synthesis of N-Containing Heteroaromatics via Heterogeneously Transition Metal Catalysed Cross-Coupling Reactions

Molecules, 2011
N-containing heteroaromatics are important substructures found in numerous natural or synthetic alkaloids. The diversity of the structures encountered, as well as their biological and pharmaceutical relevance, have motivated research aimed at the ...
Laurent Djakovitch, Marie Genelot, Nelly Batail   +2 more
doaj   +1 more source

Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm

Photochemistry and Photobiology, EarlyView.
A phototherapy device emitting principally at 234 nm was assessed for antimicrobial efficacy against Methicillin‐resistant Staphylococcus aureus and evaluated for skin health hazards. Abstract Chronic wounds are a major healthcare issue affecting more than 10 million Americans each year, with a 5‐year survival similar to cancer and costing the ...
Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J. Brenner   +4 more
wiley   +1 more source

Trend of Use of Quinolone Antibiotics in Community-Acquired Pneumonia

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Quinolone group antibiotics are frequently used in the treatment of community-acquired pneumonia (CAP). There have also been rising safety concerns related to quinolone usage.
Kadir Burak AKGÜN, Emel CEYLAN, Mehmet KARADAĞ, Merve AYIK TÜRK   +3 more
doaj   +1 more source

Changes in the Dispensing of Antibiotics to Australian Children Between 2013 and 2023: Are We Heading in the Right Direction?

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Antimicrobial resistance (AMR) poses a critical public health issue, exacerbated by the overuse and misuse of antibiotics. Children are particularly susceptible to bacterial infections and are frequently prescribed antibiotics. Objective This study examined trends in antibiotic dispensing to children aged under 13 years in Australia
Erin Kelty, Ella Tairy, Scott Sims, Carol Orr, Amy Page, David B. Preen, Frank M. Sanfilippo, Christopher Etherton‐Beer, Ebony Quintrell   +8 more
wiley   +1 more source