Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Additionality of public R&D grants in a transition economy: the case of Eastern Germany. [PDF]
This paper examines the input and output additionality of public R&D subsidies in Western and Eastern Germany. We estimate the impact of public R&D grants on firms' R&D and innovation input.
Czarnitzki, Dirk, Licht, G
core
Association between obesity and medical expenditures among Japanese adults treated for diabetes: A secondary analysis. [PDF]
PLoS OneYonekura Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Private Agricultural R&D in the United States
The objective of this study is to analyze the determinants of private agricultural R&D investment in the United States and the liaison between public and private R&D sectors. The empirical analysis employs U.S. agricultural data for the 1970-1996 period.
Tokgoz, Simla
core
Regional variation and factors associated with average expenditure per headache disorder hospitalization in Brazil: a macrocosting analysis in the SUS (2008-2023). [PDF]
Rev Saude PublicaSouza JS +7 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Competing Demographic Drivers of Hospital Expenditures: Coexistence of the Red Herring and the Steepening Effects. [PDF]
Health EconKallestrup-Lamb M +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Trends and expenditures in polypharmacy and hyperpolypharmacy among older adults in the United States, 2002-2017. [PDF]
BMC GeriatrHsu H +6 more
europepmc +1 more source