Results 101 to 110 of about 226,704 (244)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
LE FANTASTIQUE ROUMAIN. UNE DIACHRONIE POSSIBLE [PDF]
Studii si Cercetari Filologice: Seria Limbi Romanice, 2009 Dans le présent aricle nous nous arrêtons sur le fantastique roumain au XIXe siècle, en tant que situation générique, et sur la possibilité d’une approche diachronique.
Adriana APOSTOL
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
, 2015 International audienceL'objectif de cette communication serait effectivement de s'interroger voire d'analyser les causes de la pérennité de certains acteurs et la disparition des autres.
Amamou, Leila
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
BelphégorLe jeu vidéo Assassin’s Creed Odyssey se situe en Grèce en 431 avant Jésus-Christ, lors de la guerre du Péloponnèse. La poétesse grecque Praxilla est l’héroïne d’une extension.
Anne Debrosse
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Pitannâ LìteraturoznavstvaCet article examine le processus de formation de l’image du Donbass dans la littérature ukrainienne, perçu comme une région artificiellement isolée du reste de l’Ukraine.
Світлана Наместюк +2 more
doaj +1 more source