Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
»Lost in translation«. Übersetzung und kultureller Dialog
Trivium, 2013 Bernd Stiegler
doaj +1 more source
Trends in childhood obesity for upper tier local authorities in England between 2007/08 and 2023/24: a latent trajectory analysis. [PDF]
J Public Health (Oxf)Rahilly J, Cortina-Borja M, Mytton O.
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Die deutschsprachige Mauss-Rezeption
Trivium, 2014 Stephan Moebius, Frithjof Nungesser
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Ayushman Bharat Health Account (ABHA) Integration in Action: Identifying Operational Barriers at a Tertiary Care Center in Eastern India. [PDF]
CureusDagar V +4 more
europepmc +1 more source
Sébastien Charles, Berkeley au siècle des Lumières. Immatérialisme et scepticisme au XVIIIe siècle, Paris, Vrin, coll. « Bibliothèque d’histoire de la philosophie », 2003, 370 pages. [PDF]
, 2005 Jaffro, Laurent
core +1 more source