Results 91 to 100 of about 543,991 (236)

La solicitud pública de representación en la propuesta de Código Mercantil [PDF]

, 2015
En el Derecho de sociedades español la solicitud pública de representación ha significado la principal forma de controlar al representante del accionista en las juntas generales de las sociedades anónimas y, en especial, de las sociedades cotizadas. El
Zubiri de Salinas, Mercedes
core   +2 more sources

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Efecte del tipus d'embassament en el règim de cabals mínims a la conca del riu Ebre [PDF]

, 2013
En el marc dels cabals ambientals o "ecològics", el coneixement de la regulació del règim de cabals mínims o baixos per part de les infraestructures hidràuliques pren especial importància.
Garrigó, Marc, Quer i Sardanyons, Lluís, Universitat Autònoma de Barcelona. Facultat de Ciències   +2 more
core  

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Fundamentos constitucionales del sistema acusatorio colombiano, nuevo régimen probatorio del derecho penal, del principio de permanencia de la prueba a la inmediación de la prueba [PDF]

, 2013
El propósito del artículo, es realizar un análisis desde una perspectiva constitucional, acerca de la modificaciones que se introdujeron a la Constitución Política de Colombia de 1991 con el acto legislativo No.
Amaya Torres, Ana Delia, Cáceres Naranjo, Deiby Alfredo   +1 more
core  

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Anàlisi de l’evolució i situació actual de les escoles de música i/o dansa reconegudes a les Illes Balears [PDF]

, 2012
Aquest article pretén analitzar la repercussió i l’abast que les escoles de música i/o dansa reconegudes tenen sobre l’ensenyament de la música, en l’àmbit dels estudis de règim especial, a la Comunitat Autònoma de les Illes Balears, amb la finalitat de ...
Berbel Gómez, Noemy
core  

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

El sector ganadero bovino colombiano y sus problemáticas fiscales. Análisis del alcance del régimen simple de tributación

Revista de Derecho Fiscal
El sector ganadero colombiano, por muchos años, ha sido marginado en las políticas públicas que se adoptan en Colombia, en especial aquellas que regulan los tributos.
Julián Eduardo Saray Castillo
doaj   +1 more source