Results 101 to 110 of about 543,991 (236)

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Sobre la excedencia especial del personal docente e investigador universitario en régimen laboral [PDF]

, 2015
En los últimos años ha sido frecuente en nuestro país que los convenios colectivos que regulan las condiciones de trabajo del personal docente e investigador de las universidades públicas, introduzcan diferentes cláusulas de equiparación de derechos y ...
Gutiérrez Alonso, Juan J.
core  

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

La doctrina del Consejo de Transparencia sobre materias clasificadas

Revista Española de la Transparencia
El régimen de las materias clasificadas no es un régimen especial de acceso cualquiera, sino que constituye precisamente el reverso del régimen de transparencia pública.
Severiano Fernández Ramos
doaj   +1 more source

La guarda y custodia compartida y su manifestación a través del Plan de Parentalidad [PDF]

, 2017
En el presente trabajo se estudia la institución de la guarda y custodia compartida y su carácter preferente frente a la guarda y custodia individual, en especial en el ordenamiento catalán.
Gallardo Porras, Antonio, Universitat Autònoma de Barcelona. Facultat de Dret   +1 more
core  

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Zonas francas en Colombia: beneficios tributarios en el impuesto de renta [PDF]

Este documento presenta la medición de los beneficios en el impuesto de renta otorgados a las empresas que operan en las zonas francas, los cuales están representados por una tarifa diferencial del 15% y, hasta el año 2010, por una deducción especial por
Jorge Ramos F., Karen Rodríguez Z.
core  

Ciutats catalanes de l'Antic Règim : la reforma del govern municipal de Girona el 1601 [PDF]

, 1992
El autor traza un cuadro del espíritu y organización de las ciudades en el Antiguo Régimen (siglos XVI-XVII), recabando con especial intensidad en la reforma del gobierno municipal de Girona en 1601.The author draws a picture of the spirit and ...
Busquets, Joan
core   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source