Results 81 to 90 of about 257,667 (247)

Los servicios públicos locales: reforma de la Administración local en tiempos de crisis económica

open access: yes, 2015
Este trabajo se centra en el intento de la Ley 27/2013, de Racionalización y Sostenibilidad de la Administración Local, de limitar, al socaire del principio de equilibrio presupuestario, los servicios públicos que hasta el momento venían prestando las ...
Juan Antonio Chinchilla   +5 more
core   +1 more source

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian   +7 more
wiley   +1 more source

Municipios urbanos versus municipios rurales: homogeneidad y diversidad en el régimen local [PDF]

open access: yes, 2020
El régimen local español es tradicionalmente homogéneo, al menos desde los inicios del siglo xix. Esta alta homogeneidad contrasta con la diversidad de regímenes locales en otros países, normalmente federales o descentralizados.
Velasco Caballero, Francisco
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Autonomía Local, Régimen Local Básico y Reformas Estatutarias

open access: yesRevista de Estudios de la Administración Local y Autonómica, 2009
Luciano Parejo Alfonso
doaj   +3 more sources

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

open access: yesAdvanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh   +7 more
wiley   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang   +8 more
wiley   +1 more source

Bailouts in Costa Rica as a Result of Government Centralization and Discretionary Transfers [PDF]

open access: yes
This paper investigates the inter-relation between the central government and the municipalities in Costa Rica. It examines episodes in which the central government has bailed out the local governments from their obligations.
Alexander Monge-Naranjo   +2 more
core  

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li   +16 more
wiley   +1 more source

El fomento de las fusiones de ayuntamientos en el régimen de Franco, desde la ley de bases de régimen local de 1945 hasta la ley 48/1966, de 23 de julio, sobre modificación parcial del régimen local: Evolución en la provincia de Guadalajara

open access: yes, 2020
A finales de la década de los sesenta e inicios de los setenta del siglo pasado se va a producir el mayor número de fusiones de municipios en España durante el siglo XX, la consumación de la mayoría de dichas fusiones se producirá a partir de 1966 ...
BERMEJO BATANERO, FERNANDO
core  

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