Results 91 to 100 of about 257,667 (247)

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang   +7 more
wiley   +1 more source

El principio de autonomía local en el régimen vasco del gobierno local

open access: yesRevista Vasca de Administración Pública, 2017
This paper aims at specifying the legal system rationale for the Basque Country¿s local government, the terms of its insertion within the Constitutional and legal framework at the National level ¿with a broad interpretation, including, therefore, both ...
Luciano Parejo Alfonso
doaj   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu   +8 more
wiley   +1 more source

Régimen local. Elecciones. Expropiaciones y contratos

open access: yes, 2012
This case addresses issues regarding the status and functioning of local bodies such as the compulsory purchase carried out by the local council individually; a works contract where there are several delegations for its implementation; various issues ...
Fernández-Corredor Sánchez-Diezma, Javier
core  

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

open access: yesAdvanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka   +4 more
wiley   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

open access: yesAdvanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li   +6 more
wiley   +1 more source

Las reglas constitucionales sobre la interiorización del régimen local en los Estatutos de Autonomía de segunda generación y la problemática naturaleza jurídica de la Ley reguladora de las Bases de Régimen Local

open access: yes, 2013
All the Statutes of Autonomy of Autonomous Regions passed in Spain since 2006, have added a specific regulation about local system in their articles. This phenomenon has been ratified by the Constitutional Court but with some conditions, one of them ...
Alvarez García, Vicente
core  

Los problemas de la estructura poblacional y municipal de España: principales instrumentos y medidas para paliarlos en la legislación básica sobre régimen local

open access: yes, 2021
[ES] Partiendo del hecho de que España es una sociedad esencialmente urbana radicada en un territorio mayoritariamente rural, que tiene problemas de dispersión de la población en municipios muy pequeños y de una fuerte concentración en un pequeño número,
González Iglesias, Miguel Ángel   +1 more
core  

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

open access: yesAdvanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

open access: yesAdvanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu   +8 more
wiley   +1 more source

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