Results 111 to 120 of about 257,667 (247)
Advanced Science, EarlyView.Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li +4 more
wiley +1 more source
Advanced Science, EarlyView.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral +7 more
wiley +1 more source
Evolución y perspectivas del régimen competencial local en Catalunya
Aquest treball té per objecte analitzar el règim jurídic actual de les competències locals amb una visió evolutiva que parteix de la seva configuració inicial i abordar les principals reformes que han afectat la regulació fins a l’estat actual.
Vallés i Fort, Carme
core +1 more source
A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy
Advanced Science, EarlyView.ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun +12 more
wiley +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
Caso práctico: el régimen disciplinario de los cuerpos de policía local
El presente trabajo consiste en un análisis del régimen disciplinario general de los Cuerpos de Policía Local y en concreto del régimen aplicable en Castilla y León, como consecuencia de las cuestiones planteadas sobre dicha materia.
Rojo Sánchez, Andrea
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, 2010 La implementación y puesta en marcha de la planta de procesamiento de brócoli Alimentos Nariño bajo el régimen de zona franca permanente especial en el municipio de Ipiales, es un macro proyecto que ejercerá presión positiva y negativa sobre los tres ...
Revelo Jiménez, Victor Hugo +1 more
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Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Este trabajo pretende analizar el tratamiento jurídico que el ordenamiento español otorga a las grandes aglomeraciones urbanas, con especial atención a los mecanismos previstos para adaptar el régimen local a la complejidad de estos espacios ...
Vilalta Reixach, Marc
core +1 more source
Advanced Science, EarlyView.This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo +11 more
wiley +1 more source