Results 121 to 130 of about 669,721 (248)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Tuberculosis in advanced chronic kidney disease: An Observational Study at a Tertiary Care Center in Mexico. [PDF]

PLoS One
Hernández-Ibarra JA, Mercado-Torres TR, Ruiz-Ruiz JR, Román-Montes CM, Rajme-López S, Martínez-Guerra A, González-Lara F, Rivera-Villegas HO, Guy Z, Roblero-Abadía ADC, de-León AP, Sifuentes-Osornio J, Tamez-Torres KM.   +12 more
europepmc   +1 more source

Understanding Productivity Levels, Dispersion and Growth in the Leather Shoe Industry: Effects of Size and Informality [PDF]

In this case study performed on the industrial sub-sector of manufacture of leather shoes in Bolivia, we use the Hsieh and Klenow model (2008) to determine the differences between productivity of larger and formal companies and productivity of smaller ...
Carlos Gustavo Machicado, Juan Cristóbal Birbuet   +1 more
core  

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Effective of local morphine, ketorolac, and bupivacaine in pediatric tendon surgery: a randomized controlled trial. [PDF]

Sci Rep
Wongcharoenwatana J, Adulkasem N, Ariyawatkul T, Eamsobhana P, Chotigavanichaya C.   +4 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

El papel de los servicios de interés general en la reforma de la legislación española de régimen local

Revista de Estudios de la Administración Local y Autonómica, 2008
Casimiro López García
doaj   +3 more sources

Advances in the research on radiotherapy for lung cancer: a 2025 review. [PDF]

Transl Lung Cancer Res
Deng J, Zhu Z.
europepmc   +1 more source

From Locational Fundamentals to Increasing Returns: The Spatial Concentration of Population in Spain, 1787-2000 [PDF]

Does population follow the same inverted-U pattern of concentration/dispersion that has been found in the case of economic activity in the long run? In this paper we present the evidence for eight European countries during the nineteenth and twentieth ...
Fernando Collantes, María Isabel Ayuda, Vicente Pinilla   +2 more
core  

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source