Results 131 to 140 of about 257,667 (247)

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Situación actual del régimen local en Extremadura

Revista de Estudios de la Administración Local y Autonómica, 2007
Ana M.ª Nieto Guerrero Lozano
doaj   +3 more sources

TAR-0520, a new candidate in oncodermatology: Results of a phase 1 program in healthy volunteers. [PDF]

Support Care Cancer
Andres P, Winckle G, Lamquin A, Czernielewski J.   +3 more
europepmc   +1 more source

La demografía en la crisis del Antiguo Régimen

, 1987
Análisis de la relevancia de los estudios demográficos para la historia local y relación de fuentes para su tratamiento en la transición del Antiguo Régimen al Régimen Liberal.Antzinako Erregimenetik Erregimen Liberalerako trantsizioan ikerketa ...
GARCÍA-SANZ MARCOTEGUI, Ángel
core  

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

LAS BASES DE REGIMEN LOCAL.

Revista de Estudios de la Administración Local y Autonómica, 1945
Carlos Ruiz Del Castillo
doaj   +3 more sources

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Systemic corticosteroid bridging followed by ultrasound-guided microwave ablation for recurrent male plasma cell mastitis: a case report. [PDF]

Gland Surg
Yao H, Yin J, Li L, Li W, Saiding A.
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

El papel de los servicios de interés general en la reforma de la legislación española de régimen local

Revista de Estudios de la Administración Local y Autonómica, 2008
Casimiro López García
doaj   +3 more sources