Results 141 to 150 of about 257,667 (247)
Using biofilm-targeting local antibiotics to treat recalcitrant medical device-associated infections: driveline infection as a model. [PDF]
J Antimicrob ChemotherQu Y, Kaye DM, McGiffin D, Peleg AY.
europepmc +1 more source
, 2016 Dos sentencias constitucionales recientes (SSTC 41/2016 y 111/2016, sobre la reforma local de 2013) cobran gran relevancia desde la perspectiva de la estructura territorial de España.
Medina Alcoz, Luis
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Reprogramming the Immune Landscape of Inflammatory Breast Cancer
Advanced Science, EarlyView.Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez +3 more
wiley +1 more source
Anti-PD-1 monoclonal antibody combined with chemotherapy for porocarcinoma: a case report and literature review. [PDF]
Front OncolZhao G, Han G, Yang X, Jia Y.
europepmc +1 more source
NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment
Advanced Science, EarlyView.NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang +8 more
wiley +1 more source
El control interno en el ámbito local: situación actual y propuestas de reforma.
, 2012 El propósito de este trabajo es señalar, a partir de algunos datos y hechos, las deficiencias que presentan actualmente el régimen jurídico, la organización y las funciones que configuran el control interno de carácter económico financiero que existe en ...
Sesma Sánchez, Begoña
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Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
ANALYSIS OF THE DECENTRALIZATION OF PUBLIC SPENDING IN SPAIN
This paper studies the decentralization process of public spending in Spain, which has been one of the main landmarks in recent years, and not only in Spain but also in many different countries.
Molero, Juan Carlos
core
Advanced Science, EarlyView.The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian +9 more
wiley +1 more source
Advanced Science, EarlyView.Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang +8 more
wiley +1 more source