Results 91 to 100 of about 65,591 (246)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Reparación integral en los delitos de violencia de género en la justicia indígena

Revista Metropolitana de Ciencias Aplicadas, 2022
El presente trabajo de investigación se centró en la reparación integral de los delitos de violencia de género en la justicia indígena del Ecuador. Con el objetivo de evidenciar si existe reparación integral de las víctimas de violencia de género dentro ...
Lucy M. Ordoñez Salazar, Martha A. Morales Navarrete   +1 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Repair and redress: A research program for algorithmic futures

Big Data & Society
Fairness initiatives have dominated efforts to reduce the social harms caused by algorithms in society. To date, those approaches have proven inadequate. We thus trouble the fairness paradigm, suggesting a reorientation towards repair and redress.
Jenny L Davis, Apryl Williams
doaj   +1 more source

REPARATION OF THE MORAL PREJUDICES IN ROMANIAN LABOR LAW [PDF]

Challenges of the Knowledge Society, 2013
Recent decisions issued by national labor Courts contain interesting references to the problem of the moral prejudices’ reparation (especially suffered by the employee). During the application of Romanian Labor Code – Law no. 53/20031, the Courts offered
AURELIAN GABRIEL ULUITU, IOANA PĂDURARIU   +1 more
doaj  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Introduction. Mémoire(s), politique et sociétés dans les Amériques

Cahiers du MIMMOC, 2023
Diana Burgos-Vigna, Julien Zarifian
doaj   +1 more source

Implementation of the Damages Directive in England & Wales [PDF]

, 2015
The Dossier discusses the questions arising from the need to implement the EU Damages Directive 2014/104/EU in several European Member States.
Amaro, R, Bass, A, Bien, F, Camesasca, P, Choné-Grimaldi, A, Hitchings, P, Loras, L, Malo, M, Pietrini, S, Wagner-von Papp, F   +9 more
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source