Results 51 to 60 of about 65,591 (246)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

ReGeneraTing Agents (RGTA®): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand

open access: yesClinical Case Reports, 2019
Key Clinical Message CACIPLIQ20® significantly improved the outcomes of severe burn injuries of the hand. Healing was accelerated, with little or no scarring, allowing for greater mobility over the joints and maintained suppleness.
Sharifah Ahmad Roohi, Denis Barritault
doaj   +1 more source

Droit public Comparé, Système de droit contemporain et Diversité Culturelle [PDF]

open access: yes, 2011
Les efforts pour créer une Cour pénale internationale au niveau global remontent à la fin du 19e siècle, quand Gustave Moynier- l’un des fondateurs du Comité international de la Croix-Rouge propose la création d’un tribunal d’arbitrage international ...
Garcia Monteiro, Paulo Freire
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Victim, reparation and criminal process: a projection from the expressive theories of punishment

open access: yesRevista Brasileira de Direito Processual Penal, 2019
The present article tries to examine the most relevant aspects of the reparation of crime, in favor of the victim, under the assumption of the so-called “expressive theories of punishment”.
Rámon Beltrán Calfurrapa
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Les droits des victimes des crimes d’agression : est-ce une matière vague ou une notion simplement oubliée ? [PDF]

open access: yesMouvements et Enjeux Sociaux
Les droits des victimes des crimes d’agression révèlent une facette bien particulière de la réparation. Très souvent à travers des nombreuses études, on a souvent relevé la complexité des réparations dues aux victimes des crimes internationaux et on a ...
Josué Evariste SHABANI MUGUNDA
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Importance économique du Port Autonome de Liège: rapport 2003 [PDF]

open access: yes
The Port Autonome de Liège, with its 26 kilometres of berths and several multimodal platforms, plays an important role in the Walloon and Belgian economy.
Frédéric Lagneaux
core  

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