Results 71 to 80 of about 65,591 (246)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

De la réparation à la restauration

open access: yesRevue de Géographie Alpine, 2010
In this article, we analysed how the objectives behind the revegetation of ski trails have evolved since the 1970’s. Our approach was based on a sociological survey. We show that the revegetation was first launched in order to repair the scars due to the
Céline Granjou   +2 more
doaj   +1 more source

La Reconstruction et ses conséquences en France (fin des années 1910-années 1920) [PDF]

open access: yes, 2015
Version française d'un article de l'International Encyclopedia of the First World War : "France : Post-War Economies"Lien : http://encyclopedia.1914-1918-online.net/article/post-war_economies_franceL’ensemble des pays belligérants doivent faire face, au ...
Le Bras, Stéphane
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Le renforcement de la responsabilité pénale en matière de pollution maritime [PDF]

open access: yes, 2010
Après le naufrage de l'Erika et du Prestige, les dispositions répressives concernant les rejets illicites d’hydrocarbures à partir des navires ont été modifiées à trois reprises (lois du 3 mai 2001, du 9 mars 2004 et du 1er août 2008 ...
Monteiro, Evelyne
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Ce que le développement fait au traitement d’un passé violent. Élites et pratiques de la « réparation communautaire » au Maroc

open access: yesRevue Gouvernance, 2019
Cet article analyse le programme de réparation communautaire issu des recommandations formulées en 2005 par l’Instance Équité et Réconciliation, la Commission vérité marocaine.
Frédéric Vairel
doaj   +1 more source

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