Results 111 to 120 of about 298,783 (242)
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Tour de France de la répression
, 1981 Tour de France de la répression. In: Cahiers du féminisme, n°17, 1981. Droit à l'emploi pour toutes, avortement libre et gratuit, équipements collectifs : Chiche !
core +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Les trois volets de la répression : réflexion autour d'un concept envahissant
, 1983 Lombard J. Les trois volets de la répression : réflexion autour d'un concept envahissant . In: L'Homme et la société, N. 67-68, 1983. Répression emprise violence. pp.
Lombard, Jacques
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Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Répression et effectivité de la norme environnementale
, 2014 A quoi sert la répression en matière d’environnement si ce n’est à assurer l’effectivité de la norme ? C’est du moins ce qu’incline à penser le caractère finaliste du droit de l’environnement.
Bétaille, Julien
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A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice
Advanced Science, EarlyView.A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing +26 more
wiley +1 more source
, 2018 La répression des infractions en matière de protection de la faune sauvage et de leurs habitats découle d'objectifs instaurés au niveau supranational. En Belgique, les instruments régionaux qui l'organisent prévoient deux types de répression.
Smargiassi, Naïke
core
, 2022 Alors que l’insurrection ouvrière de juin de 1848 et les rébellions contre le coup d’État du 2 décembre 1851 avaient été réprimées par des juridictions d’exception, la première par des commissions militaires, les secondes par les commissions mixtes de ...
Farcy, Jean-Claude
core
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source