Results 41 to 50 of about 471,262 (228)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Perception locale et stratégies d'adaptation face aux risques d'inondation, de sécheresse et de feux de végétation dans la partie septentrionale du bassin du Mono (Togo) : enjeux socio-économiques et environnementaux

Revue Ecosystèmes et Paysages
Le bassin du Mono est crucial tant sur le plan environnemental qu'économique, fournissant des ressources vitales et régulant les écosystèmes. Cette étude évalue les perceptions locales des risques d'inondation, de sécheresse et de feux de végétation, et ...
Narouwa Ndigridema, Lamboni Payéne, Magamana Essossimna, Badjaré Bilouktime, Atato Abalo, Dourma Marra, Tozo Koffi, Batawila Komlan, Akpagana Koffi   +8 more
doaj   +1 more source

Résilience, adaptation, changement : l’interdisciplinarité questionnée [PDF]

Natures Sciences Sociétés, 2014
La troisième conférence internationale du réseau Resilience Alliance « Résilience et développement : mobiliser pour la transformation », s’est tenue à Montpellier du 4 au 8 mai 2014.
Hervé Dominique, Rivière Mylène
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Exposition à la violence conjugale, traumatisme psychique et reconstruction identitaire en contexte ivoirien [PDF]

Pensées Genre, Penser Autrement
Cet article examine la violence conjugale observée par Elise, ses effets sur le traumatisme psychique et la reconstruction identitaire dans le contexte ivoirien.
N’GUESSAN Yao Richard
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Esthétique de l’effondrement dans le monde francophone

Revue Nordique des Études Francophones
Ce numéro spécial de la Revue nordique des études francophones explore l’esthétique de l’effondrement dans le monde francophone, en analysant les discours et les représentations littéraires, artistiques et philosophiques qui émergent face aux crises ...
Sara Bédard-Goulet, Christophe Premat
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source