Results 51 to 60 of about 418,934 (246)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Les distorsions cognitives prédisent-elles le stress perçu et la résilience dans une population non-clinique ?

Cortica
Les distorsions cognitives sont rarement mentionnées dans la littérature sans que l’on parle également de la dépression. Le but de cette recherche menée sur une population non- clinique est d’investiguer le lien entre les distorsions ...
Vinciane Darbellay
doaj   +1 more source

OBSERVER LA RESILIENCE RURALE REFLEXIONS THEORIQUES ET APPLICATION DANS LES CAMPAGNES CENTRAFRICAINES [PDF]

, 2010
N° ISBN - 978-2-7380-1284-5International audienceThis paper aims to assess the conceptual and empirical scope of the concept of resilience, for studying high risky rural contexts. Resilience is first defined at the individual level, and evaluated through
Lallau, Benoît, Mbetid-Bessane, Emmanuel   +1 more
core   +1 more source

Adaptation et résilience : Favoriser la recherche de sens chez les personnes atteintes de sclérose en plaques [PDF]

, 2009
S’adapter à la sclérose en plaques (SEP) constitue un défi renouvelé au quotidien. La conceptualisation du processus d’adaptation pour les personnes atteintes de SEP à partir des théories sur le deuil permet une réflexion ouvrant sur des pistes d ...
Couture, Christiane
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Des systèmes agro-sylvo-pastoraux innovants pour nourrir l'Afrique de l'Ouest et du Centre [PDF]

, 2013
El desgaste laboral es una sensación compleja, integrada por síntomas físicos y psíquicos, que ubica a quien la percibe desde sentirse bien hasta estar exhausto.
Yapy-Gnaore, Valentine, Vall, Eric, Havard, Michel, Kanwé, Augustin, Sangaré, Mamadou   +4 more
core   +2 more sources

L’expression musicale en réadaptation : Une approche favorisant la résilience [PDF]

, 2009
Une activité d’expression musicale est offerte au Centre de réadaptation Lucie-Bruneau (CRLB) pour les personnes atteintes de sclérose en plaques et leurs proches.
Beaudry, Denise, Dumais, Mélanie, Fortin, Audrey   +2 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source