Results 121 to 130 of about 3,025,660 (244)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Résistance !

, 1995
Sandrine . Résistance !. In: Marie Pas Claire, n°6, 1995. Changeons d'ère : Renversons le patriarcat ! pp.
Sandrine
core  

Les "mots" de la résistance

, 2020
International audienceAvant d'entamer le dossier, voici un petit glossaire à l'usage des gestionnaires de la résistance aux produits phytopharmaceutiques.La résistance aux PPP est un phénomène souvent complexe, faisant appel à des notions de biochimie ...
Network, R4p, Debieu, Daniele, Siegwart, Myriam, Le Goff, Gaëlle, Délye, Christophe, Fillinger, Sabine, Walker, Anne-Sophie, Barrès, Benoît, Plantamp, Christophe, Hannachi, Mourad, Corio-Costet, Marie-France, Gauffre, Bertrand   +11 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

L'Effort. L'Avenir de l'ouvrier. Publié par la Jeune résistance

, 1944
21 mars 19441944/03/21 (N1)
Jeune résistance. Auteur du texte
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

High prevalence of bla NDM gene among a series of carbapenem-resistant Enterobacterales isolates from children less than one year old in Niger

BMC Microbiology
Background Carbapenem-resistant Enterobacterales are increasingly reported worldwide, posing significant treatment challenges, especially in vulnerable pediatric populations.
Issoufou Noma Massir, Yacouba Abdourahamane, Tapha Ounoussa, Hamidou Oumou, Ousmane Abdoulaye, Aminatou Ousmane, Moussa Harouna, Brah Souleymane, Mahamadou Doutchi, Mamadou Saidou, Ibrahim Mamane Laminou   +10 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Les résistances en Europe

, 2011
Arte diffuse à partir du mercredi 12 octobre une série documentaire consacrée aux résistances européennes : "Les Combattants de l'ombre". Ce documentaire semble s'inscrire dans le prolongement des quelques travaux de recherche menés depuis les années ...
ch2r
core