Results 121 to 130 of about 13,281,844 (310)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The information matrix test with bootstrap-based covariance matrix estimation. [PDF]

We propose an information matrix test in which the covariance matrix of the vector of indicators is estimated using the parametric bootstrap. Monte Carlo results and heuristic arguments show that its small sample performance is comparable with that of ...
Hoorelbeke, Dirk, Dhaene, Geert
core   +2 more sources

Theoretical calculations and analysis for n + 6Li reaction

EPJ Web of Conferences, 2017
R-matrix theory is an important methodology for applications on light, medium and heavy mass nuclides nuclear reaction in the resonance energy range. Full R-matrix formalism contains the diagonal elements of the energy levels matrix and it is a rigorous ...
Tao Xi, Wang Jimin, Chen Guochang, Shen Qingbiao   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

spam: A Sparse Matrix R Package with Emphasis on MCMC Methods for Gaussian Markov Random Fields

spam is an R package for sparse matrix algebra with emphasis on a Cholesky factorization of sparse positive definite matrices. The implemantation of spam is based on the competing philosophical maxims to be competitively fast compared to existing tools ...
Reinhard Furrer, Stephan R. Sain
core  

Shortcomings of the R-matrix method for treating dielectronic recombination

, 2002
By performing radiation-damped R-matrix scattering calculations for the photorecombination of Fe17+ forming Fe16+, we demonstrate and discuss the difficulties and fundamental inaccuracies associated with the R-matrix method for treating dielectronic ...
Savin, Daniel Wolf, Gorczyca, T. W., Badnell, N. R.   +2 more
core   +1 more source

Twin Toughening‐Driven Martensitic Transformation Strategy Synergistic Improvement for Plasticity‐Thermal Shock Resistance of (Hf─Zr─Ti)C Ceramic Coating in Severe Thermal Environments

Advanced Science
The inherent brittleness and insufficient thermal shock resistance of ultra‐high temperature ceramic (UHTC) in severe thermal environments (above 2000 °C) remain significant challenges.
Jiachen Li, Yulei Zhang, Yanqin Fu, Tao Li, Jian Zhang, Deyu Yang, Lingfei Cao, Fanyu Lu, Junhao Zhao, Junshuai Lv, Hejun Li   +10 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

mpmsim: An R package for simulating matrix population models

Methods in Ecology and Evolution
Matrix population models (MPMs) are widely used in ecology and evolution to explore population dynamics, including assessing management impacts and extinction risk. In comparative studies, MPMs can be used to test life‐history theory or investigate macro‐
Owen R. Jones
doaj   +1 more source