Results 111 to 120 of about 17,969,489 (257)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

mpmsim: An R package for simulating matrix population models

Methods in Ecology and Evolution
Matrix population models (MPMs) are widely used in ecology and evolution to explore population dynamics, including assessing management impacts and extinction risk. In comparative studies, MPMs can be used to test life‐history theory or investigate macro‐
Owen R. Jones
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Uniform exponential growth for some SL(2,R) matrix products [PDF]

, 2009
Given a hyperbolic matrix $H\in SL(2,\R)$, we prove that for almost every $R\in SL(2,\R)$, any product of length $n$ of $H$ and $R$ grows exponentially fast with $n$ provided the matrix $R$ occurs less than $o(\frac{n}{\log n\log\log n ...
Roblin, Thomas, Avila, Artur
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

R EcolLett matrix models incl Fig S5

, 2018
R script with matrix models that estimate net reproductive rate (lambda) for each source at the three highest sites (ie across R. minor’s high-elevation range limit) on each transect.
Anna Hargreaves (5950493), Hargreaves, Anna, Eckert, Chris, Chris Eckert (5950505)   +3 more
core   +1 more source

Determine the Determinant of 4xn Non-Square Matrix Using Radić’s Determinant

UJM (Unnes Journal of Mathematics)
A non-square matrix is a matrix that has a different number of rows and columns. In the modified double-guard Hill cipher algorithm, a non-square matrix is used as the private key matrix that plays a role in the message encryption and decryption process.
Intan Wahyuningsih, Kristina Wijayanti
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Regularization of the transformation matrix of R-algorithm [PDF]

, 2018
Предлагается модификация r-алгоритма, предназначенная для предотвращения вырождения матрицы, обратной к матрице преобразования пространства. Этот вариант r-алгоритма целесообразно использовать для задач минимизации существенно овражных функций ...
Лиховид, А.П., Журбенко, Н.Г.   +1 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source