Results 91 to 100 of about 17,969,489 (257)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Characterisation and Application Studies of Sophorolipid Biosurfactant by Candida tropicalis RA1

Journal of Pure and Applied Microbiology, 2019
The present study reports isolation of Candida tropicalis RA1 from oil contaminated refinery soil. The study depicted production of 31 g sophorolipid (SLs) l-1 by Candida tropicalis RA1 until 240 h, using soya oil.
Rutuja Ankulkar, Meera Chavan
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An efficient algorithm for computing real powers of a matrix and a related matrix function [PDF]

, 1988
summary:The paper is devoted to an algorithm for computing matrices $A^r$ and $(A^r -I).(A-I)^{-1}$ for a given square matrix $A$ and a real $r$. The algorithm uses the binary expansion of $r$ and has the logarithmic computational complexity with respect
Ježek, Jan
core   +1 more source

Tailor-made 3D printing TPU/PLA composites for damping and energy absorption

Materials & Design
Commercially available thermoplastic polyurethane (TPU) materials for 3D printing often exhibit inadequate damping properties, limiting their application in damping scenarios.
Ruichao Zu, Wenzheng Chen, Yicang Huang, Yujie Chen, Chengzhen Du, Qunfu Fan, Hua Li, Hezhou Liu   +7 more
doaj   +1 more source

Rank relations between a {0, 1}-matrix and its complement

Open Mathematics, 2018
Let A be a {0, 1}-matrix and r(A) denotes its rank. The complement matrix of A is defined and denoted by Ac = J − A, where J is the matrix with each entry being 1.
Ma Chao, Zhong Jin
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Correlation matrix for multiple IPQ-R domains.

, 2016
Correlation matrix for multiple IPQ-R domains.
Tarek Bellaj (3278856), Hédia Bellali (3278850), Mohamed Kouni Chahed (632636), Sonia Ben Jemaa (3278853)   +3 more
core   +1 more source