Results 71 to 80 of about 13,281,844 (310)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
matrix-profile-foundation/tsmp: Fixed clang-UBSAN errors
, 2022 R Functions implementing UCR Matrix Profile ...
Francisco Bischoff +2 more
core +1 more source
Atiyah classes of three-dimensional Lie bialgebras over Z_3
四川大学学报. 自然科学版, 2019 Based on the theory of Lie algebra cohomology and the definition of the Atiyah class of a Lie bialgebra, Atiyah classes of all three-dimensional Lie bialgebras over Z_3 are calculated.
SHEN Dan-Dan
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]
, 2009 Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Braun, Thomas +9 more
core +1 more source
Communications Biology, 2021 Malvezzi et al. discuss the impact of BRD4 phosphorylation on the formation of dimers and identify the key residues necessary for this dimerization. They also discuss the differential role of monovalent and bivalents bromodomain inhibitors regarding the ...
Francesca Malvezzi +9 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
R-matrix analysis of ^{16}O compound nucleus reactions
, 2013 Background: Over the past 60 years, a large amount of experimental nuclear data have been obtained for reactions which probe the 16O compound nucleus near the α and proton separation energies, the energy regimes most important for nuclear astrophysics ...
P. J. LeBlanc +5 more
core +1 more source
A versatile R-matrix module including alternative parametrizations [PDF]
EPJ Web of ConferencesThe evaluation of nuclear reaction data within the resolved resonance regime relies on phenomeno-logical R-matrix analyses. In absence of quantitatively reliable microscopic models phenomenological R-matrix manages to reproduce experiment data at high ...
Srdinko Thomas, Leeb Helmut
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source