Results 61 to 70 of about 17,969,489 (257)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Optimal solution of the nearest correlation matrix problem by minimization of the maximum norm [PDF]
The nearest correlation matrix problem is to find a valid (positive semidefinite) correlation matrix, R(m,m), that is nearest to a given invalid (negative semidefinite) or pseudo-correlation matrix, Q(m,m); m larger than 2.
Mishra, SK
core
Chern–Simons theory and the R-matrix
, 2021 It has been a long-standing problem how to relate Chern–Simons theory to the quantum groups. In this paper we recover the classical r-matrix directly from a three-dimensional Chern–Simons theory with boundary conditions, thus creating a direct link to ...
Aamand, Nanna Havn, Nanna Havn Aamand
core +1 more source
SciPost PhysicsA bootstrap program is presented for algebraically solving the univariate $R$-matrix of a generic integrable quantum spin chain from its Hamiltonian.
Zhao Zhang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Columnwise Update Algorithm for Sparse Stochastic Matrix Factorization
, 2022 Nonnegative matrix factorization arises widely in machine learning and data analysis. In this paper, for a given factorization of rank r, we consider the sparse stochastic matrix factorization (SSMF) of decomposing a prescribed m-by-n stochastic matrix V
Ching, W, Bai, Z, Xiao, G
core +1 more source
A versatile R-matrix module including alternative parametrizations [PDF]
EPJ Web of ConferencesThe evaluation of nuclear reaction data within the resolved resonance regime relies on phenomeno-logical R-matrix analyses. In absence of quantitatively reliable microscopic models phenomenological R-matrix manages to reproduce experiment data at high ...
Srdinko Thomas, Leeb Helmut
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source