Results 81 to 90 of about 17,969,489 (257)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

UKRMol:UKRmol-out

open access: yes, 2019
<p>Outer region programs for the UK computational implementation of the R-matrix method for the treatment of electron and positron scattering from molecules (GTOs only).</p> <p>For a complete list of the authors who contributed to this
UK R-matrix community (8226705)   +1 more
core   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

open access: yesAdvanced NanoBiomed Research
Endometriosis (EM) results in pelvic adhesions and chronic inflammation, which significantly reduce embryo implantation and the clinical pregnancy rates of in vitro fertilization (IVF), affecting 190 million women worldwide.
Zhou Liang   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

R-matrix and Mickelsson algebras for orthosymplectic quantum groups

open access: yes, 2015
Let be a complex orthogonal or symplectic Lie algebra and ′ ⊂ the Lie subalgebra of rank rk ′ = rk  − 1 of the same type. We give an explicit construction of generators of the Mickelsson algebra Zq(, ′) in terms of Chevalley generators via the R-matrix
Andrey Mudrov (7627877)   +1 more
core   +3 more sources

Instanton R-matrix and W $$ \mathcal{W} $$ -symmetry

open access: yesJournal of High Energy Physics, 2019
We study the relation between W 1 + ∞ $$ {\mathcal{W}}_{1+\infty } $$ algebra and Arbesfeld-Schiffmann­ Tsymbaliuk Yangian using the Maulik-Okounkov R-matrix. The central object linking these two pictures is the Miura transformation. Using the results of
Tomáš Procházka
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

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