Results 51 to 60 of about 3,575,531 (267)

Size-exclusion chromatography as a multi-attribute method for process and product characterization of adeno-associated virus

Molecular Therapy: Methods & Clinical Development
Adeno-associated viruses (AAVs) have recently emerged as a leading platform for gene therapy. Due to the complex manufacturing process and structural features of AAVs, extensive process and product characterization studies are required to better ...
Sri Hari Raju Mulagapati, Arun Parupudi, Tomasz Witkos, Nick Bond, Xiaoyu Chen, Thomas Linke, Guoling Xi, Albert Ethan Schmelzer, Wei Xu   +8 more
doaj   +1 more source

Evaluation of micropillar array columns for chromatographic separation of phosphorothioated oligonucleotides and their diastereomers

Analytical Science Advances, 2021
Chromatographic analysis of therapeutic oligonucleotides is challenging due to the presence of closely related impurities, degradants or metabolites and due to the presence of phosphorothioate bonds, which introduce chiral centers.
Lieve Dillen, Tiny Deschrijver, Kurt Van Mol, Jeff Op de Beeck, Paul Jacobs, Filip Cuyckens   +5 more
doaj   +1 more source

On the Nucleosynthetic Origin of Presolar Silicon Carbide X-Grains

Universe, 2022
In this paper we present an extension of our nucleosynthesis parameter study within the classical neutrino-driven wind scenario of core-collapse supernovae (ccSNe).
Waheed Akram, Oliver Hallmann, Bernd Pfeiffer, Karl-Ludwig Kratz   +3 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Critical Assessment of Activities of Structural Units in Fe–Al Binary Melts Based on the Atom and Molecule Coexistence Theory

High Temperature Materials and Processes, 2018
A thermodynamic model for calculating the mass action concentrations Ni{N_i} of structural units in Fe–Al binary melts based on the atom–molecule coexistence theory, i. e., AMCT–Ni{N_i} model, has been developed and verified to be valid by comparing with
Yang Xue-min, Li Jin-yan, Yan Fang-jia, Duan Dong-ping, Zhang Jian   +4 more
doaj   +1 more source

Lasers for the observation of multiple order nuclear reactions

Frontiers in Physics, 2022
Nuclear reaction rates become nonlinear with respect to flux (cm−2s−1) in extreme environments such as those found during stellar nucleosynthesis and terrestrial nuclear detonations.
Jeffrey Burggraf, Alex Zylstra
doaj   +1 more source

The r-Process and Chronometers

, 2002
4 pages, 2 figures; In Proceedings of the 11th Workshop on Nuclear Astrophysics, eds. W. Hillebrandt and E.
Cowan, John J., Sneden, Christopher, Truran, James W.   +2 more
openaire   +2 more sources

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

A note on r-processes

Brazilian Journal of Probability and Statistics, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source