Results 1 to 10 of about 12,715 (182)

CD38 symmetric dimethyl site R58 promotes malignant tumor cell immune escape by regulating the cAMP-GSK3β-PD-L1 axis. [PDF]

Heliyon
In recent years, immunotherapy has emerged as an effective approach for treating tumors, with programmed cell death ligand 1 (PD-L1)/programmed cell death protein-1 (PD-1) immune checkpoint blockade (ICB) being a promising strategy. However, suboptimal therapeutic efficacy limits its clinical benefit.
Liang L, Yue C, Li W, Tang J, He Q, Zeng F, Cao J, Liu S, Chen Y, Li X, Zhou Y.   +10 more
europepmc   +4 more sources

Design and optimization of a semi-trailer extendable RUPD according to UNECE R58

Engineering Perspective, 2022
Extensive tests was carried out on the rear protection equipment of a tipper-type silobus semi-trailer. This study includes the design and optimization process of an extensible rear underrun protective device for O4 category semi-trailers. Material selection and structural design features were evaluated within the framework of harmonization with ...
Fakı Binboğa, Ebubekir Hubeyb Şimşek
openaire   +2 more sources

Investment Financing from EU Funds as a Factor of Local Development on the Example of the Włodawa Town and the Włodawa Commune

Studia Ekonomiczne i Regionalne, 2022
Subject and purpose of work: The subject-matter of this paper are local government investments and their role in local development. The aim of the paper is to evaluate the use of EU funds for the implementation of local investments on the example of the ...
Adamowicz Mieczysław, Stolarczyk Katarzyna   +1 more
doaj   +1 more source

Relationship Between Children’s Enjoyment, User Experience Satisfaction, and Learning in a Serious Video Game for Nutrition Education: Empirical Pilot Study

JMIR Serious Games, 2020
BackgroundThe design and use of serious video games for children have increased in recent years. To maximize the effects of these games, it is essential to understand the children’s experiences through playing.
Espinosa-Curiel, Ismael Edrein, Pozas-Bogarin, Edgar Efrén, Martínez-Miranda, Juan, Pérez-Espinosa, Humberto   +3 more
doaj   +1 more source

Changes in the core-Periphery Structure of the Framework Programme’s Regional Network

Studia Ekonomiczne i Regionalne, 2023
The aim of this paper is to measure whether the regions lagging behind in the European knowledge field could get closer to the core of the Framework Programmes’ (FP) R&D network.
Bilicz Dávid
doaj   +1 more source

Doppler imaging and surface differential rotation of young open cluster stars - I. HD 307938 (R58) in IC 2602 [PDF]

Monthly Notices of the Royal Astronomical Society, 2005
ISSN:0035 ...
Marsden, S. C., Waite, I. A., Carter, B. D., Donati, J.-F.   +3 more
openaire   +4 more sources

Borderland Location as a Factor of the Development of the Terespol Commune

Studia Ekonomiczne i Regionalne, 2021
Subject and purpose of work: The aim of the study was to determine the significance of the borderland location as a factor in the development of the Terespol commune.
Guzal-Dec Danuta, Bartniczuk Kamila, Zwolińska-Ligaj Magdalena   +2 more
doaj   +1 more source

Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease

Heliyon, 2019
Transforming growth factor-β (TGF-β) is a key driver for liver fibrogenesis. TGF-β must be activated in order to function. Plasma kallikrein (PLK) is a TGF-β activator that cleaves the latency-associated protein (LAP) between arginine58 and lysine59 ...
Hiroshi Yokoyama, Takahiro Masaki, Ikuyo Inoue, Mariko Nakamura, Yoshihiro Mezaki, Chisato Saeki, Tsunekazu Oikawa, Masayuki Saruta, Hiroyuki Takahashi, Masahiro Ikegami, Hiroshi Hano, Kenichi Ikejima, Soichi Kojima, Tomokazu Matsuura   +13 more
doaj   +1 more source

Characterization of site‐directed mutants of residues R58, R59, D116, W340 and R372 in the active site of E. coli cystathionine β‐lyase [PDF]

Protein Science, 2010
AbstractCystathionine β‐lyase (CBL) catalyzes the hydrolysis of L‐cystathionine (L‐Cth) to produce L‐homocysteine, pyruvate, and ammonia. A series of active‐site mutants of Escherichia coli CBL (eCBL) was constructed to investigate the roles of residues R58, R59, D116, W340, and R372 in catalysis and inhibition by aminoethoxyvinylglycine (AVG).
Pratik H, Lodha, Allison F, Jaworski, Susan M, Aitken   +2 more
openaire   +2 more sources

Accurate first-derivative nonadiabatic couplings for the H3 system [PDF]

, 2001
A conical intersection exists between the ground (1 2 A[prime]) and the first-excited (2 2A[prime]) electronic potential energy surfaces (PESs) of the H3 system for C3v geometries.
Abrol, Ravinder, Kuppermann, Aron, Shaw, Amy, Yarkony, David R.   +3 more
core   +1 more source