Results 11 to 20 of about 2,710 (224)

Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease

Heliyon, 2019
Transforming growth factor-β (TGF-β) is a key driver for liver fibrogenesis. TGF-β must be activated in order to function. Plasma kallikrein (PLK) is a TGF-β activator that cleaves the latency-associated protein (LAP) between arginine58 and lysine59 ...
Hiroshi Yokoyama, Takahiro Masaki, Ikuyo Inoue, Mariko Nakamura, Yoshihiro Mezaki, Chisato Saeki, Tsunekazu Oikawa, Masayuki Saruta, Hiroyuki Takahashi, Masahiro Ikegami, Hiroshi Hano, Kenichi Ikejima, Soichi Kojima, Tomokazu Matsuura   +13 more
doaj   +2 more sources

Genetic Differentiation in the SdhC Subunit Confers Intrinsic Resistance to SDHI Fungicides in Fusarium asiaticum. [PDF]

Mol Plant Pathol
In Fusarium asiaticum, two homologous SdhC subunits (FaSdhC1/C2) regulate sensitivity to SDHI fungicides: deletion of FaSDHC1 decreases sensitivity, while deletion of FaSDHC2 increases it. Multiple mutations in ΔFaSDHC2 confer resistance to SDHI fungicides.
Song J, Wang J, Liu X, Liu Y, Bi L, Li M, Cai Y, Zhou M, Duan Y.   +8 more
europepmc   +2 more sources

Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth. [PDF]

J Physiol
Abstract figure legend Increases in testosterone are associated with developmental changes in motor‐related neural oscillations in youth. Abstract Motor control is critical to daily functioning and undergoes significant refinement throughout youth. Although the effects of age on the underlying brain circuitry have been well characterized, fewer studies
Derby J, Ward TW, Petro NM, Son JJ, Ende GC, Rice DL, Coutant AT, Steiner EL, Calhoun VD, Wang YP, Stephen JM, Heinrichs-Graham E, Wilson TW.   +12 more
europepmc   +2 more sources

AcrVA3 Is a Double Strand DNA-Cleaving Anti-CRISPR That Indirectly Inhibits Cas12. [PDF]

FASEB J
This study reports the high‐resolution structure of the anti‐CRISPR protein AcrVA3 and reveals its unexpected inhibitory mechanism against Cas12. AcrVA3 does not directly interact with Cas12 but instead exhibits double‐stranded DNA cleavage activity.
Han JH, Kang YJ, Lee SY, Jin HB, Lee CS, Park HH.   +5 more
europepmc   +2 more sources

Intravascular Lithotripsy Is Associated With Superior Clinical Outcomes Compared to Atherectomy: A Large-Scale, Propensity-Matched Analysis. [PDF]

Catheter Cardiovasc Interv
ABSTRACT Background Coronary artery disease (CAD) with severe calcification remains a growing challenge in percutaneous coronary intervention (PCI). Atherectomy (ATH) has long been used for plaque modification, whereas intravascular lithotripsy (IVL) has emerged as a promising alternative. Large‐scale comparative data on long‐term outcomes are limited.
Miks CD, Ozaki GK, Shukla CR, Sharma V.
europepmc   +2 more sources

Clinical and Genetic Landscape of Glioblastoma, IDH-Wildtype With FGFR Gene Family Alterations. [PDF]

Cancer Sci
We analyzed 1076 cases of glioblastoma, IDH‐wildtype (GBM, IDH‐wt) using the C‐CAT genomic database to clarify the clinical and genetic features of FGFR alterations. FGFR::TACC fusions and FGFR1 mutations were identified in distinct subsets and were associated with unique co‐mutation patterns.
Kegoya Y, Otani Y, Mizuta R, Ikemachi R, Kamiura M, Ishida J, Toyooka S, Ennishi D, Tomida S, Tanaka S.   +9 more
europepmc   +2 more sources

Rural-Urban Migration, Structural Transformation, and Housing Markets in China

American Economic Journal: Macroeconomics, 2023
This paper investigates the interrelationship between urbanization, structural transformation, and the post-2000 Chinese housing boom through the lens of a dynamic spatial equilibrium model that features migration and a rich housing market structure with
Carlos Garriga, Aaron Hedlund, Yang Tang, Ping Wang   +3 more
semanticscholar   +1 more source

The Assessment of Three Measures (101, 103, 302) Under the National Plan of Agriculture and Rural Development of Kosovo

Studia Ekonomiczne i Regionalne, 2020
Subject and purpose of work: Agriculture has historically been an important sector in Kosovo’s economy however the biggest challenges are migration, land fragmentation, and access to market and finance.
Krasniqi Nol, Nagy Henrietta
doaj   +1 more source

Investment Financing from EU Funds as a Factor of Local Development on the Example of the Włodawa Town and the Włodawa Commune

Studia Ekonomiczne i Regionalne, 2022
Subject and purpose of work: The subject-matter of this paper are local government investments and their role in local development. The aim of the paper is to evaluate the use of EU funds for the implementation of local investments on the example of the ...
Adamowicz Mieczysław, Stolarczyk Katarzyna   +1 more
doaj   +1 more source

European Funds for Rural Areas and Regional Convergence of Agriculture in Poland

Studia Ekonomiczne i Regionalne, 2019
Subject and purpose of work: The aim of the article is to assess the phenomena of sigma convergence of labour productivity in agriculture and other sectors of rural economy in Polish regions during 2003 – 2014 in the context of the amount of European ...
Adamowicz Mieczysław
doaj   +1 more source