CD38 symmetric dimethyl site R58 promotes malignant tumor cell immune escape by regulating the cAMP-GSK3β-PD-L1 axis. [PDF]
HeliyonIn recent years, immunotherapy has emerged as an effective approach for treating tumors, with programmed cell death ligand 1 (PD-L1)/programmed cell death protein-1 (PD-1) immune checkpoint blockade (ICB) being a promising strategy. However, suboptimal therapeutic efficacy limits its clinical benefit.
Liang L +10 more
europepmc +5 more sources
Doppler imaging and surface differential rotation of young open cluster stars - I. HD 307938 (R58) in IC 2602 [PDF]
Monthly Notices of the Royal Astronomical Society, 2005 ISSN:0035 ...
S C Marsden, I A Waite, B D Carter
exaly +5 more sources
R58. Ps. Arnaldus de Vilanova / Nicolaus Comes (Nicolaus de Comitibus)?/ Iohannes de Thesen? [PDF]
Lateinische Dialoge 1200-1400, 2007 C Cardelle De Hartmann
exaly +6 more sources
Design and optimization of a semi-trailer extendable RUPD according to UNECE R58
Engineering Perspective, 2022 Extensive tests was carried out on the rear protection equipment of a tipper-type silobus semi-trailer. This study includes the design and optimization process of an extensible rear underrun protective device for O4 category semi-trailers. Material selection and structural design features were evaluated within the framework of harmonization with ...
Fakı Binboğa, Ebubekir Hubeyb Şimşek
openaire +3 more sources
Characterization of site‐directed mutants of residues R58, R59, D116, W340 and R372 in the active site of E. coli cystathionine β‐lyase [PDF]
Protein Science, 2010 AbstractCystathionine β‐lyase (CBL) catalyzes the hydrolysis of L‐cystathionine (L‐Cth) to produce L‐homocysteine, pyruvate, and ammonia. A series of active‐site mutants of Escherichia coli CBL (eCBL) was constructed to investigate the roles of residues R58, R59, D116, W340, and R372 in catalysis and inhibition by aminoethoxyvinylglycine (AVG).
Pratik H, Lodha +2 more
openaire +3 more sources
Biochemical and genetic dissection of the RNA-binding surface of the FinO domain of Escherichia coli ProQ. [PDF]
RNA, 2023 RNA-binding proteins play important roles in bacterial gene regulation through interactions with both coding and non-coding RNAs. ProQ is a FinO-domain protein that binds a large set of RNAs in Escherichia coli, though the details of how ProQ binds these
Stein EM +6 more
europepmc +2 more sources
Stronger binding affinities of gp120/CD4 in Catarrhini provide insights into HIV/host interactions. [PDF]
Infect Dis ModelHuman immunodeficiency virus-1 (HIV-1) exploits the viral gp120 protein and host CD4/CCR5 receptors for the pandemic infection to humans. The host co-receptors of not only humans but also several primates and HIV-model mice can interact with the HIV ...
Li V, Lee C, Park T, Jarvis ED, Kim H.
europepmc +2 more sources
Changes in the core-Periphery Structure of the Framework Programme’s Regional Network
Studia Ekonomiczne i Regionalne, 2023 The aim of this paper is to measure whether the regions lagging behind in the European knowledge field could get closer to the core of the Framework Programmes’ (FP) R&D network.
Bilicz Dávid
doaj +1 more source
JMIR Serious Games, 2020 BackgroundThe design and use of serious video games for children have increased in recent years. To maximize the effects of these games, it is essential to understand the children’s experiences through playing.
Espinosa-Curiel, Ismael Edrein +3 more
doaj +1 more source
Borderland Location as a Factor of the Development of the Terespol Commune
Studia Ekonomiczne i Regionalne, 2021 Subject and purpose of work: The aim of the study was to determine the significance of the borderland location as a factor in the development of the Terespol commune.
Guzal-Dec Danuta +2 more
doaj +1 more source