Results 1 to 10 of about 9,809 (206)

A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation [PDF]

PeerJ, 2023
Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues. MSU crystals activate the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)
Supattra Charoenwutthikun, Kasem Chanjitwiriya, Sittiruk Roytrakul, Duangkamol Kunthalert   +3 more
doaj   +4 more sources

Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility [PDF]

Frontiers in Chemistry
IntroductionShort-acting ketamine-related scaffold design remains an important medicinal-chemistry problem, but computational studies require conservative interpretation until receptor, enzymatic, and pharmacokinetic validation is available.MethodsS ...
Ahmed A. A. M. M. Alkhatip, Ahmed A. A. M. M. Alkhatip, Usama Raza, Ehab Farag, Mohamed Khaled Hamza, Hisham Hosny, Hisham Hosny, Amr Sallam, Ahmed M. G. Farag, Mohamed Wagih, Amr Naguib, Ahmed Mostafa Abdulmegid, Haytham Algameel, Mahmoud Hussein Bahr   +13 more
doaj   +2 more sources

From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody [PDF]

Frontiers in Immunology
IntroductionThe rapid evolution of SARS-CoV-2 Omicron variants highlights the urgent need for therapeutic strategies that can target viral evolution and leverage host immune recognition mechanisms.
Shuyuan Cao, Bo Sun, Feng Gao, Feng Gao, Feng Gao   +4 more
doaj   +2 more sources

A Retrospective Comparative Study on Arthroscopic-Assisted Uni-Portal Spinal Surgery (AUSS/UNSES) Versus Unilateral Biportal Endoscopy for Double-Segment Lumbar Spinal Stenosis. [PDF]

Orthop Surg
This retrospective comparative study demonstrates that Arthroscopic‐Assisted Uni‐portal Spinal Surgery (AUSS/UNSES) for double‐segment lumbar stenosis achieves equivalent 12‐month clinical outcomes to Unilateral Biportal Endoscopy (UBE), while offering significant perioperative advantages including shorter operative time, reduced drainage and ...
Liu Z, Song E, Hao S, Li X, Yao Y, Zhong J.   +5 more
europepmc   +2 more sources

Drug Metabolism and Pharmacokinetic Evaluation of a Novel RNase H2 Inhibitor for the Treatment of Triple-Negative Breast Cancer [PDF]

Pharmaceutics
Objectives: A thorough understanding of pharmacokinetics and metabolism is critical during early drug development. This study investigates the absorption, distribution, metabolism, and excretion (ADME) profile of R14, a novel compound, using a ...
Yang Wang, Huan Xie, Jing Ma, Ting Du, Song Gao, Yuan Chen, Shiaw-Yih Lin, Dong Liang   +7 more
doaj   +2 more sources

Effect of Distance to Train Station and Mobile Coverage on Land Value: A Case of Tax Valuation in Oreamuno, Costa Rica

Baltic Journal of Real Estate Economics and Construction Management, 2022
In Costa Rica, a land tax valuation model provided by the Technical Standardization Body (ONT) of the Ministry of Finance is used. This model considers homogeneous areas that include properties with similar characteristics and review factors that have ...
Molina Javier Paniagua, Gómez Sergio Ulate, Thompson Johanna Solórzano, Navarro David Barboza   +3 more
doaj   +1 more source

“Lex Developer” in Practice - The Scale of Application in the Largest Polish Cities

Real Estate Management and Valuation, 2022
State intervention in the housing market can take many different forms. In Poland, in 2018, a lex specialis regulation was introduced to the general principles of spatial policy in terms of special privileges for developers operating in the housing ...
Załęczna Magdalena, Antczak-Stępniak Agata   +1 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Diversification of agricultural activity in the territorial breakdown of Lubuskie Province

Folia Oeconomica Stetinensia, 2023
Each type of administrative unit, including cities, towns and villages, plays a different role in the regional economy. In the case of rural areas, their most important function is agricultural production.
Szczuciński Przemysław
doaj   +1 more source

On the Assocıated Curves of a Frenet Curve in R_1^4

Cumhuriyet Science Journal, 2022
In the present work, we have dealt with the properties of associated curves of a Frenet curve in R14. In addition to this, we define principal direction curve, B_1 -direction curve, B_2- direction curve of a given Frenet curve by using integral curves ...
Mehmet Bektaş, Münevver Yıldırım Yılmaz, Esra Çiçek Çetin   +2 more
doaj   +1 more source