From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody [PDF]
Frontiers in ImmunologyIntroductionThe rapid evolution of SARS-CoV-2 Omicron variants highlights the urgent need for therapeutic strategies that can target viral evolution and leverage host immune recognition mechanisms.
Shuyuan Cao +4 more
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Drug Metabolism and Pharmacokinetic Evaluation of a Novel RNase H2 Inhibitor for the Treatment of Triple-Negative Breast Cancer [PDF]
PharmaceuticsObjectives: A thorough understanding of pharmacokinetics and metabolism is critical during early drug development. This study investigates the absorption, distribution, metabolism, and excretion (ADME) profile of R14, a novel compound, using a ...
Yang Wang +7 more
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Growth, sporulation and production of bioactive compounds by Bacillus subtilis R14 [PDF]
Brazilian Archives of Biology and Technology, 2010 The physiology of B. subtilis R14 was investigated in minimal medium under excess-oxygen and oxygen-limited conditions. Growth and efficient sporulation could be achieved in excess-oxygen culture on medium with readily metabolizable carbon and nitrogen ...
André Lacerda Ulysses de Carvalho +4 more
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The study of thermodynamic properties of zeotropic mixtures of R600a/R23/R14 [PDF]
Advances in Mechanical Engineering, 2017 Thermodynamic properties of zeotropic mixtures of R600a/R23/R14 have been investigated and calculated based on the established mathematical model. The deviations of bubble pressure and vapor composition between the simulation results and the experimental
Yinlong Wu +4 more
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Phospholamban R14 Deletion Results in Late-Onset, Mild, Hereditary Dilated Cardiomyopathy
Journal of the American College of Cardiology, 2006 The purpose of this research was to determine the phenotypic spectrum associated with phospholamban gene (PLN) mutations.Inheritance contributes to the development of dilated cardiomyopathy. Mutations in the gene encoding PLN have been associated with dilated cardiomyopathy characterized by early onset and the presence of lethal ventricular arrhythmias.
Elizabeth Mcnally, Betty Soliven
exaly +3 more sources
A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation [PDF]
PeerJ, 2023 Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues. MSU crystals activate the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)
Supattra Charoenwutthikun +3 more
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Baltic Journal of Real Estate Economics and Construction Management, 2022 In Costa Rica, a land tax valuation model provided by the Technical Standardization Body (ONT) of the Ministry of Finance is used. This model considers homogeneous areas that include properties with similar characteristics and review factors that have ...
Molina Javier Paniagua +3 more
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“Lex Developer” in Practice - The Scale of Application in the Largest Polish Cities
Real Estate Management and Valuation, 2022 State intervention in the housing market can take many different forms. In Poland, in 2018, a lex specialis regulation was introduced to the general principles of spatial policy in terms of special privileges for developers operating in the housing ...
Załęczna Magdalena +1 more
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Diversification of agricultural activity in the territorial breakdown of Lubuskie Province
Folia Oeconomica Stetinensia, 2023 Each type of administrative unit, including cities, towns and villages, plays a different role in the regional economy. In the case of rural areas, their most important function is agricultural production.
Szczuciński Przemysław
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