Results 101 to 110 of about 1,255 (213)

Studying Vulnerable Code Entities in R

open access: yesProceedings of the 32nd IEEE/ACM International Conference on Program Comprehension
5 pages, 3 figures, and 2 tables.
Zixiao Zhao   +2 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A note on R-extensible prefix codes

open access: yesSemigroup Forum, 1989
A prefix code P over X is said to be r-extensible if for every uv\(\in P\) and \(x\in X^*\) there exists \(s\in X^*\) such that \(uxv=ts\) for some \(t\in P\). An ideal I of \(X^*\) is said to be cs-prime if \(x^ 2\in I\) implies that \(x\in I\). In this note, a necessary and sufficient condition for an r-extensible prefix code to be finite is given ...
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

(R)evolution of Programming: Vibe Coding as a Post-Coding Paradigm

open access: yesCoRR
Workshop Contribution at the sixth decennial Aarhus conference in "The End of Programming (as we know it) - Envisioning Radical Re-Conceptualizations of Co-Coding with AI"
Kevin Krings   +2 more
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Some New Optimal Skew Cyclic Codes With Derivation

open access: yesIEEE Access
Our study included a class of cyclic codes named $\delta _{\alpha,\zeta }-$ cyclic codes over the ring $\mathcal {R}=\mathbb {F}_{2^{m}} + u\mathbb {F}_{2^{m}}+u^{2}\mathbb {F}_{2^{m}}$ , where m is an odd positive integer with $u^{3}=1$ . These codes
Asia Noor   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

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