Results 141 to 150 of about 4,657,009 (295)
Beta-lactamase of R factors [PDF]
J, Evans +3 more
openaire +2 more sources
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Factors of Trusting in International Business [PDF]
The paper reports on an online survey that set out to identify some of the factors of trusting. The survey was open to all nationalities and asked a broad variety of questions regarding individual choices of trusting.
Illes, K., Krishna, R.
core
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Determination of Purlin R-factors Using a Non-linear Analysis
In both Australia and the U.S.A., the design procedure for purlins under wind uplift loading is based on the use of reduction factors (R-factors), which allow for the flexural-torsional or nonlinear twisting behaviour of purlins with screw-fastened ...
Hancock, Gregory J. +1 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
\((r,r+1)\)-factorizations of \((d,d+1)\)-graphs
A \((d,d+1)\)-graph is a graph all of whose vertices have degrees in the set \([d,d+1]\). Such a graph is \textit{semiregular}. An \((r,r+1)\)-factorization of a graph \(G\) is a decomposition of \(G\) into \((r,r+1)\)-factors. For \(d\)-regular simple graph \(G\) we determine for which \(x\) and \(r\) \(G\) must have an \((r,r+1)\)-factorization with ...
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source

