Results 121 to 130 of about 4,657,009 (295)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

R Factors of Compatibility Group A [PDF]

Journal of General Microbiology, 1973
N, Datta, R W, Hedges
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Financial Constraint and R&D Investment: Evidence from CIS [PDF]

Using direct information on financial constraints from questionnaires, rather than the commonly used balance sheet information, this paper presents evidence that, controlling for traditional factors as size, market share, cooperative arrangement, and ...
Schim van der Loeff, Sybrand, Mohnen, Pierre, Tiwari, Amaresh, Palm, Franz   +3 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

ITKids: Is paper IT work more physically variable than computer IT work for children?

, 2007
Children are spending more time than ever on computers for school and leisure and the effect of computer use on their developing musculoskeletal systems is of concern.
Burgess-Limerick, Robin, Straker, Leon M., Coleman, J., Straker, L., Pollock, Clare M. (R20416), Burgess-Limerick, R., Pollock, C., Coleman, Jemma L.   +7 more
core  

Heterogeneity in ALSFRS-R decline and survival: a population-based study in Italy

, 2015
Very few studies examined trend over time of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and factors influencing it; previous studies, then, included only patients attending tertiary ALS Centres.
D'Alessandro, R., Rizzi, R., Mussuto, V., Tugnoli, V., Santangelo, M., Terlizzi, E., Canali, E., Granieri, E., Fasano, A., Pasquinelli, M., AIELLO, Marina, Michelucci, R., Georgoulopoulou, E., Groppo, E., Neri, W., Borghi, A., Amidei, S., Sacquegna, T., Grassi, A., De Pasqua, S., Chierici, E., Gabellini, A., Tola, M. R., De Massis, P., Avoni, P., Rinaldi, R., Guidi, C., Montanari, E., Delay, L., Ferro, S., Andruccioli, J., Pietrini, V., Marcello, N., Salvi, F., Greco, G., Passarin, M. G., Ravasio, A., Venturini, E., Sette, E., Bartolomei, I., ERRALS Group, Currò Dossi, M., Fini, N., Liguori, R., Biguzzi, S., Cirignotta, F., D’Alessandro, R., PIETRINI, Vladimiro, Nichelli, P., Guidetti, D., Casmiro, M., Rasi, F., Casetta, I., Mandrioli, J.   +53 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

(r,r)-disynephrine ether bis(hydrogen sulfate)

, 2009
The asymmetric unit of the title compound [systematic name: (R, R)-2,4-bis(4-hydroxyphenyl)-N,N'-dimethyl-3-oxapentane-1,5- diammonium bis(hydrogen sulfate)], C18H26N2O32+center dot-2HSO(4)(-), contains one half-cation and one hydrogen sulfate anion. The
Arbuckle, William, Morrison, Catriona A., Catriona A. Morrison, Arbuckle, W., Kennedy, A.R., Alan R. Kennedy, Morrison, C.A., Kennedy, Alan R., William Arbuckle   +8 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source