Results 1 to 10 of about 208,533 (137)

Extrachromosomal inheritance in bacteria

Bacteriological Reviews, 1969
Richard Novick
exaly   +7 more sources

Extrachromosomal inheritance of oligomycin resistance in yeast

FEBS Letters, 1970
K. Wakabayashi, N. Gunge
exaly   +4 more sources

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

bioRxiv, 2023
The chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes on different chromosomes assort independently, providing a fundamental tenet of Mendelian ...
King L. Hung, Matthew G. Jones, I. Wong, Joshua T. Lange, J. Luebeck, Elisa Scanu, B. J. He, Lotte Brückner, Rui Li, Rocío Chamorro González, R. Schmargon, J. Dörr, Julia A. Belk, V. Bafna, B. Werner, Weini Huang, A. Henssen, P. Mischel, Howard Y. Chang   +18 more
semanticscholar   +3 more sources

Extrachromosomal circular DNA are functional, heritable units that expand genomic plasticity and confer resilience [PDF]

Frontiers in Plant Science
Although far less well-known and understood than chromosomal DNA, extrachromosomal circular DNA (eccDNA) are a pervasive and dynamic component of eukaryotic genomes.
Dana R. MacGregor, Christopher A. Saski
doaj   +2 more sources

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Nature
The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1.
King L. Hung, Matthew G. Jones, I. Wong, Ellis J Curtis, Joshua T. Lange, B. J. He, J. Luebeck, R. Schmargon, Elisa Scanu, Lotte Brückner, Xiaowei Yan, Rui Li, Aditi Gnanasekar, R. Chamorro González, Julia A. Belk, Zhonglin Liu, Bruno Melillo, V. Bafna, J. Dörr, Benjamin Werner, Weini Huang, Benjamin F. Cravatt, A. Henssen, P. Mischel, Howard Y. Chang   +24 more
semanticscholar   +3 more sources

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma [PDF]

Nature Genetics, 2018
To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models derived from them.
A. deCarvalho, Hoon Kim, L. Poisson, M. Winn, Claudius Mueller, David Cherba, Julie M. Koeman, S. Seth, A. Protopopov, M. Felicella, Siyuan Zheng, A. Multani, Yongying Jiang, Jianhua Zhang, D. Nam, E. Petricoin, L. Chin, T. Mikkelsen, R. Verhaak   +18 more
semanticscholar   +4 more sources

Extrachromosomal inheritance of carbon dioxide sensitivity in the mosquito Culex quinquefasciatus. [PDF]

Genetics, 1983
ABSTRACT Mosquitoes from a laboratory colony of Culex quinquefasciatus from Matsu Island, China, develop irreversible paralytic symptoms after exposure to carbon dioxide at 1°. This CO2 sensitivity is caused by an inherited infectious agent, probably a virus.
D. Shroyer, L. Rosen
semanticscholar   +3 more sources

Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers. [PDF]

Cancer Discov
Extrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance through its asymmetric mitotic segregation.
Montuori G, Tu F, Qin D, Schmargon R, Rodriguez-Fos E, Helmsauer K, Hui H, Mandal S, Purshouse K, Fankhänel L, Bosco B, Spanjaard B, Seyboldt H, Grunewald L, Schmitt MJ, Gürgen D, Buck V, Rosenfeldt MT, Dubois FPB, Schallenberg S, Lehmann A, Theißen J, Taschner-Mandl S, Koch A, Hundsdoerfer P, Künkele A, Eggert A, Fischer M, Gargiulo G, Krieger TG, Chavez L, Coscia F, Werner B, Huang W, Henssen AG, Dörr JR.   +35 more
europepmc   +2 more sources

Reciprocal extrachromosomal inheritance in rye (Secale cereale L.) [PDF]

Hereditas, 2009
In an inbred line of Steel rye (Stalrag), a chlorophyll mutant (status paralbomaculatus) arose spontaneously that displayed both extrachromosomal maternal and paternal inheritance in crosses.
S. Fröst, Ludvigs Vaivars, C. Carlbom
semanticscholar   +2 more sources

Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing

Cell Reports
Summary: The non-Mendelian inheritance of extrachromosomal DNA (ecDNA) exacerbates tumor genomic heterogeneity and evolution. Due to short-read sequencing’s reconstruction deficiencies, ecDNA abundance in clinical tumor tissues requires further ...
Ruoming Sun, Zongkai Li, Yi Liu, Yanbing Hou, Bowen Zhao, Chunpeng Chen, Jingwen Fang, Chuang Guo, Ying Zhou, Kun Qu, Shouzhen Li   +10 more
doaj   +2 more sources