Cancer: From a Genetic Disorder to a Systemic Disease. [PDF]
Adv Sci (Weinh)Advanced Science, Volume 12, Issue 42, November 13, 2025.
Wong AH, Hu Y.
europepmc +2 more sources
Research Advances of Extrachromosomal Circular DNA in Breast Cancer. [PDF]
Cancer MedABSTRACT Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.
Zhu X +6 more
europepmc +2 more sources
Nature CommunicationsBorgs are huge extrachromosomal elements (ECE) of anaerobic methane-consuming “Candidatus Methanoperedens” archaea. Here, we used nanopore sequencing to validate published complete genomes curated from short reads and to reconstruct new genomes.
Marie C. Schoelmerich +18 more
doaj +3 more sources
Structure of the Enterobacter pan-genome is revealed using machine learning [PDF]
Microbiology SpectrumThe growing availability of publicly accessible Enterobacter genomes offers an opportunity to reveal the structure of its pangenome, uncovering the catalog of genes across the genus and their distribution across the different species and subspecies of ...
Joshua T. Burrows +4 more
doaj +2 more sources
Connecting the dots: Epigenetic regulation of extrachromosomal and inherited DNA amplifications. [PDF]
J Biol ChemDNA amplification has intrigued scientists for decades. Since its discovery, significant progress has been made in understanding the mechanisms promoting DNA amplification and their associated function(s). While DNA copy gains were once thought to be regulated purely by stochastic processes, recent findings have revealed the important role of ...
Azadegan C, Santoro J, Whetstine JR.
europepmc +3 more sources
Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution [PDF]
Abstract Gene amplification in the form of extrachromosomal DNA (ecDNA) is a frequent driver in multiple cancer types. As ecDNA lack centromeres, their mitotic segregation does not follow traditional inheritance principles. However, the mechanisms that govern ecDNA fate following mitosis remain unclear.
Shir Marom +24 more
openaire +2 more sources
Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis. [PDF]
PLoS PathogensIntegrative and conjugative elements (ICEs) play a vital role in bacterial evolution by carrying essential genes that confer adaptive functions to the host.
Qibing Gu +6 more
doaj +2 more sources
CURRENT OPINION ON TAXONOMY, MORPHOLOGICAL, AND FUNCTIONAL PROPERTIES OF BIFIDOBACTERIA
Фундаментальная и клиническая медицина, 2018 Here we present current information on the taxonomy of bifidobacteria, which is based on their phenotypic, genetic and phylogenetic characteristics.
YULIYА V. Zakharova +1 more
doaj +1 more source
The evolutionary dynamics of extrachromosomal DNA in human cancers. [PDF]
, 2022 Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance-random identity by descent-is poorly understood.
Utkrisht Rajkumar (7174580) +21 more
core +2 more sources