Results 21 to 30 of about 208,533 (137)

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data

Oncogenesis, 2023
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
doaj   +1 more source

PlasmidHostFinder: Prediction of Plasmid Hosts Using Random Forest

mSystems, 2022
Plasmids play a major role facilitating the spread of antimicrobial resistance between bacteria. Understanding the host range and dissemination trajectories of plasmids is critical for surveillance and prevention of antimicrobial resistance ...
Derya Aytan-Aktug, Philip T. L. C. Clausen, Judit Szarvas, Patrick Munk, Saria Otani, Marcus Nguyen, James J. Davis, Ole Lund, Frank M. Aarestrup   +8 more
doaj   +1 more source

Research Advances of Extrachromosomal Circular DNA in Breast Cancer. [PDF]

Cancer Med
ABSTRACT Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.
Zhu X, Qian Y, Tang Q, Li J, Geng Y, Gong S, Jin C.   +6 more
europepmc   +2 more sources

Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma. [PDF]

Cancer Discov
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT, Pradella D, Lisi M, Kittel J, Sharma N, Bailey C, Weeden CE, Bell DM, Joo E, Barbè V, Jones MG, Hung KL, Nye EL, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Ventura A, Nicoll JAR, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B.   +34 more
europepmc   +2 more sources

EXPERIMENTAL ANALYSIS OF A PATERNALLY INHERITED EXTRACHROMOSOMAL FACTOR [PDF]

Genetics, 1986
ABSTRACT Virtually all known cases of extrachromosomal inheritance involve cytoplasmic inheritance through the maternal line. Recently, a paternally transmitted factor that causes the production of all-male families has been discovered in a parasitic wasp.
J H, Werren, J, van den Assem
openaire   +2 more sources

Inheritance of extrachromosomal rDNA in Physarum polycephalum. [PDF]

Molecular and Cellular Biology, 1983
In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how rDNA is inherited after meiosis. Two
P J, Ferris, V M, Vogt, C L, Truitt
openaire   +2 more sources

EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA

iScience, 2019
Summary: Oncogene amplification is one of the most common drivers of genetic events in cancer, potently promoting tumor development, growth, and progression.
Utkrisht Rajkumar, Kristen Turner, Jens Luebeck, Viraj Deshpande, Manmohan Chandraker, Paul Mischel, Vineet Bafna   +6 more
doaj   +1 more source

Sperm-Mediated Transgenerational Inheritance

Frontiers in Microbiology, 2017
Spermatozoa of virtually all species can spontaneously take up exogenous DNA or RNA molecules and internalize them into nuclei. In this article I review evidence for a key role of a reverse transcriptase (RT) activity, encoded by LINE-1 retrotransposons,
Corrado Spadafora
doaj   +1 more source

GENE-23. DISCORDANT INHERITANCE OF CHROMOSOMAL AND EXTRACHROMOSOMAL DNA ELEMENTS CONTRIBUTE TO DYNAMIC DISEASE EVOLUTION IN GLIOBLASTOMA [PDF]

Neuro-Oncology, 2017
A. deCarvalho, Hoon Kim, L. Poisson, Julie M. Koeman, T. Mikkelsen, R. Verhaak   +5 more
semanticscholar   +2 more sources

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

eLife, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Grant A King, Jay S Goodman, Jennifer G Schick, Keerthana Chetlapalli, Danielle M Jorgens, Kent L McDonald, Elçin Ünal   +6 more
doaj   +1 more source