Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers. [PDF]
Cancer DiscovExtrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance through its asymmetric mitotic segregation.
Montuori G +35 more
europepmc +3 more sources
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data
Oncogenesis, 2023 In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang +4 more
doaj +1 more source
PlasmidHostFinder: Prediction of Plasmid Hosts Using Random Forest
mSystems, 2022 Plasmids play a major role facilitating the spread of antimicrobial resistance between bacteria. Understanding the host range and dissemination trajectories of plasmids is critical for surveillance and prevention of antimicrobial resistance ...
Derya Aytan-Aktug +8 more
doaj +1 more source
EXPERIMENTAL ANALYSIS OF A PATERNALLY INHERITED EXTRACHROMOSOMAL FACTOR [PDF]
Genetics, 1986 ABSTRACT Virtually all known cases of extrachromosomal inheritance involve cytoplasmic inheritance through the maternal line. Recently, a paternally transmitted factor that causes the production of all-male families has been discovered in a parasitic wasp.
J H, Werren, J, van den Assem
openaire +2 more sources
Inheritance of extrachromosomal rDNA in Physarum polycephalum. [PDF]
Molecular and Cellular Biology, 1983 In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how rDNA is inherited after meiosis. Two
P J, Ferris, V M, Vogt, C L, Truitt
openaire +2 more sources
DNA Circles as Vehicles for Genes to Evade Chromosomal Discipline. [PDF]
Genome Biol EvolIn this Perspective article, we follow the journey of a gene that breaks free from its stringent chromosomal transmission dynamics to become an independently multiplying agent on so-called extrachromosomal circular DNA (ecDNA/eccDNA).
Rojas-Triana M, Boomsma JJ, Regenberg B.
europepmc +2 more sources
Characteristics of E. coli K12 strains carrying both an F prime and an R factor [PDF]
, 1970 The interrelationship between an F prime and an F-like or I-like R factor was studied in Escherichia coli K 12 strains carrying both. The donorability of such strains suggested that these plasmids were transferred independently by their own transfer ...
Finnegan, David, WILLETTS, N S
core +1 more source
Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast
eLife, 2019 Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Grant A King +6 more
doaj +1 more source
Dissection and design of yeast prions. [PDF]
, 2004 Many proteins can misfold into beta-sheet-rich, self-seeding polymers (amyloids). Prions are exceptional among such aggregates in that they are also infectious.
Cox Brian S +15 more
core +1 more source
Reciprocal extrachromosomal inheritance in rye (Secale cereale L.) [PDF]
Hereditas, 2009 In an inbred line of Steel rye (Stalrag), a chlorophyll mutant (status paralbomaculatus) arose spontaneously that displayed both extrachromosomal maternal and paternal inheritance in crosses. Striata plants gave rise to albino, striata, and normal offspring when selfed.
SUNE FRÖST +2 more
openaire +1 more source