Results 31 to 40 of about 208,533 (137)
Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 Yersinia pestis belongs to those pathogenic bacteria which produce lipopolysaccharide (LPS) having the function of a toxin. In order to make a toxic effect the polymer must be separated from the cell outer membrane and presented to the immunocompetent ...
V. I. Tynyanova +3 more
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A genetic study of a Staphylococus aureus plasmid involving cure and transference
São Paulo Medical JournalHigh frequency transfer and elimination of drug resistance may indicate an extrachromosomal inheritance of genetic determinants. This study shows the cure and transfer of a small plasmid and tetracycline resistance in Staphylococcus aureus 1030 (55)TetR ...
Ana Lúcia Costa Darini
doaj +1 more source
eLifeExtrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin +6 more
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Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Molecular insights and translational opportunities to enhance heat tolerance in rice
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
wiley +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
MedComm, Volume 7, Issue 7, July 2026.Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance
Molecules and CellsSUMMARY Extrachromosomal DNA (ecDNA) are circular DNAs that function in tumor progression and treatment resistance by amplifying oncogenes. ecDNA lack centromeres and thus are not constrained to Mendelian segregation, enabling unequal and rapid ...
Ashley Nichols +8 more
semanticscholar +1 more source
Septins in the Middle—Makers and Breakers of Membrane Contact Sites
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
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CURRENT OPINION ON TAXONOMY, MORPHOLOGICAL, AND FUNCTIONAL PROPERTIES OF BIFIDOBACTERIA
Фундаментальная и клиническая медицина, 2018 Here we present current information on the taxonomy of bifidobacteria, which is based on their phenotypic, genetic and phylogenetic characteristics.
YULIYА V. Zakharova +1 more
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Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia
Haemophilia, Volume 32, Issue 3, Page 584-592, May/June 2026.ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh +5 more
wiley +1 more source