Results 51 to 60 of about 5,488 (166)

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, Volume 19, Issue 11, Page 2999-3002, November 2025.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

Nature Communications
Borgs are huge extrachromosomal elements (ECE) of anaerobic methane-consuming “Candidatus Methanoperedens” archaea. Here, we used nanopore sequencing to validate published complete genomes curated from short reads and to reconstruct new genomes.
Marie C. Schoelmerich, Lynn Ly, Jacob West-Roberts, Ling-Dong Shi, Cong Shen, Nikhil S. Malvankar, Najwa Taib, Simonetta Gribaldo, Ben J. Woodcroft, Christopher W. Schadt, Basem Al-Shayeb, Xiaoguang Dai, Christopher Mozsary, Scott Hickey, Christine He, John Beaulaurier, Sissel Juul, Rohan Sachdeva, Jillian F. Banfield   +18 more
doaj   +1 more source

Asymmetric cell division and “differential inheritance of aging“ [PDF]

, 2009
Asimetričnom staničnom diobom nastaju stanice kćeri koje su međusobno različite. Pri takvoj diobi dolazi do diferencijalnog nasljeđivanja centrosoma, molekula DNA, molekula RNA, proteina i proteinskih agregata.
Herceg, Viktorija
core   +2 more sources

Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in maize [PDF]

, 1990
Many transposable elements in maize alternate between active and inactive phases associated with the modification of their DNA. Elements in an inactive phase lose their ability to transpose, their ability to excise from reporter alleles and, in some ...
Barkan, A., Freeling, M., Martienssen, R., Taylor, W. C.   +3 more
core   +1 more source

Maloethanolic deacidification of high acid juices during wine yeast alcoholic fermentation : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University [PDF]

, 1996
Malic acid is a major acid found in grapes. In countries with cooler climates, such as New Zealand, this acid is not fully respired from grapes and will impart a sour taste on grape juices.
Ryan, Frances Alison
core  

Survey of extrachromosomal circular DNA derived from plant satellite repeats [PDF]

, 2008
Background Satellite repeats represent one of the most dynamic components of higher plant genomes, undergoing rapid evolutionary changes of their nucleotide sequences and abundance in a genome.
Alice Navrátilová, Andrea Koblížková, Jiří Macas   +2 more
core   +1 more source

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Nature
AbstractThe chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell ...
King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Ellis J. Curtis, Joshua T. Lange, Britney Jiayu He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Xiaowei Yan, Rui Li, Aditi Gnanasekar, Rocío Chamorro González, Julia A. Belk, Zhonglin Liu, Bruno Melillo, Vineet Bafna, Jan R. Dörr, Benjamin Werner, Weini Huang, Benjamin F. Cravatt, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang   +24 more
openaire   +2 more sources

Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Yanfei Cheng, Yuanyuan Shi, Ning Sun, Xin Zhang, Mengwei Sun, Xiuping He   +5 more
wiley   +1 more source

Enhancer sharing promotes neighborhoods of transcriptional regulation across eukaryotes [PDF]

, 2016
Enhancers physically interact with transcriptional promoters, looping over distances that can span multiple regulatory elements. Given that enhancer–promoter (EP) interactions generally occur via common protein complexes, it is unclear whether EP pairing
Quintero-Cadena, Porfirio, Sternberg, Paul W.   +1 more
core   +2 more sources

Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin [PDF]

, 2017
Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components,
Hanzén, Sarah
core   +1 more source