Results 71 to 80 of about 2,871 (153)

Tools to study the rules for licensing expression and piRNA mediated epigenetic inheritance of silencing in the C. elegans germline

, 2021
In C. elegans, the germline is a tightly regulated tissue where silencing pathways regulate genes, allowing expression of “self” while silencing “non-self.” Doublestranded RNAs (dsRNAs), short interfering RNAs (siRNAs), and piwi-associated RNAs (piRNAs ...
Priyadarshini, Monika
core   +1 more source

DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA‐positive tumours

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Congcong Tian, Haiyun Gan
wiley   +1 more source

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival [PDF]

Extrachromosomal DNA (ecDNA) contributes to cancer genome instability by enabling high-copy oncogene amplification, intratumoural heterogeneity and rapid genetic change.
Brückner L, Xu R, Tang J, Gnanasekar A, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Montouri G, Pradella D, Ilić M, Suina K, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu-Kraljič M, Herzog S, Hollinger A, Wittstruck N, Fernandez M, Wolozyn N, Becker F, Louma V, Yan X, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Dawes C, Balmus G, Hero B, Fischer M, Bafna V, Verhaak R, Wahl G, Liu Y, Koche RP, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Scheer M, Werner B, Chang HY, Mischel PS, Henssen AG.   +60 more
europepmc   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. [PDF]

, 2014
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their ...
Mara Lawniczak, Wass, Mark N., Arthur M Talman, Sinden, Robert E., Prieto, Judith H, Yates, JR, Talman, Arthur M, Sinden, Robert, Michael JE Sternberg, Sinden, Robert E, Stanway, RS, Graham, David R, Marques, S, Ubaida-Mohien, Ceereena, Tao Xu, Marques, Sara, Ecker, A, Sternberg, MJ, Sternberg, Michael J E, Yates, John R., III, Prieto, JH, Talman, AM, Rhoel R Dinglasan, Xu, T, Ubaida-Mohien, C, Sanjeev Krishna, Lawniczak, Mara, Wass, MN, Wass, Mark N, Dinglasan, Rhoel R, Robert E Sinden, Talman, Arthur M., Christophides, Georges K., Christophides, Georges K, Andrea Ecker, Sara Marques, Ceereena Ubaida-Mohien, Sternberg, Michael JE, Limenitakis Stanway, Rebecca, Dinglasan, Rhoel R., Georges K Christophides, Sternberg, MJE, Yates, John R, Roland Frank, Stanway, Rebecca S., Graham, David R., Xu, Tao, Frank, Roland, Prieto, Judith H., Rebecca S Stanway, Dinglasan, RR, John R Yates, Sternberg, Michael J. E., Stanway, Rebecca S, Graham, DR, Krishna, S, Mark N Wass, Christophides, GK, Lawniczak, M, Sinden, RE, Frank, R, Krishna, Sanjeev, Ecker, Andrea, David R Graham, Judith H Prieto   +64 more
core   +1 more source

Inheritance of the yeast mitochondrial genome

, 1994
Mitochondrion, extrachromosomal genetics, intergenic sequences, genome size, mitochondrial DNA, petite mutation ...
Piskur, Jure
core  

Asymmetric inheritance is necessary but not sufficient for eccDNA accumulation.

, 2019
(A) Southern blot showing CUP1 eccDNA and ERCs for wt, spt3Δ, yku70Δ, and bud6Δ cells aged for 24 hours in the presence or absence of 1 mM CuSO4. (B) Quantification of CUP1 eccDNA and rDNA-derived ERCs in wt and spt3Δ cells aged for 24 hours in the ...
Jonathan Houseley (243535), Ryan M. Hull (4175350), Michelle King (8071997), Felix Krueger (131603), Xabier Vergara (8072003), Grazia Pizza (8072000)   +5 more
core   +1 more source

Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos

, 2011
DNA injected into the Caenorhabditis elegans germline forms extrachromosomal arrays that segregate during cell division [1, 2]. The mechanisms underlying array formation and segregation are not known.
Oegema, K, Yuen, Karen W.Y., Karen W.Y. Yuen, Arshad Desai, Nabeshima, Kentaro, Desai, A, Nabeshima, K, Oegema, Karen, Kentaro Nabeshima, Karen Oegema, Yuen, KWY, Desai, Arshad   +11 more
core   +1 more source

Replication coordination marks the domestication of large extrachromosomal replicons in bacteria

Bacterial genomes often include extrachromosomal replicons (ERs), ranging from small plasmids to nearly chromosome-sized elements, that foster genome plasticity and adaptation.
Bignaud, Amaury, Lamberioux, Morgan, Bos, Julia, Marbouty, Martial, Skovgaard, Ole, Taib, Najwa, Mazel, Didier, Czarnecki, Jakub, Bourhy, Pascale, Koszul, Romain, Val, Marie-Eve, Niault, Théophile, Bartosik, Dariusz, Krakowska, Elvira   +13 more
core   +1 more source

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer. [PDF]

Cell
Wong IT, Bailey C, Wu S, Henssen AG, Cravatt BF, Chen ZJ, Bafna V, Jamal-Hanjani M, Swanton C, Chang HY, Mischel PS.   +10 more
europepmc   +1 more source