Results 61 to 70 of about 5,488 (166)
hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan
Aging Cell, Volume 24, Issue 8, August 2025.In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam +15 more
wiley +1 more source
DNA DSB repair pathway choice: an orchestrated handover mechanism [PDF]
, 2014 DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages ...
A Kakarougkas +5 more
core +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Advanced Science, Volume 12, Issue 25, July 3, 2025.Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi +12 more
wiley +1 more source
Twisted Tales: Insights into Genome Diversity of Ciliates Using Single-Cell 'Omics. [PDF]
, 2018 The emergence of robust single-cell 'omics techniques enables studies of uncultivable species, allowing for the (re)discovery of diverse genomic features.
Katz, Laura A +4 more
core +1 more source
Therapies for Mitochondrial Disease: Past, Present, and Future
Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.ABSTRACT Mitochondrial disease is a diverse group of clinically and genetically complex disorders caused by pathogenic variants in nuclear or mitochondrial DNA‐encoded genes that disrupt mitochondrial energy production or other important mitochondrial pathways. Mitochondrial disease can present with a wide spectrum of clinical features and can often be
Megan Ball +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen +12 more
wiley +1 more source
Heteroduplex analysis of tra delta f' plasmids and the mechanism of their formation [PDF]
, 1977 Four tra delta FargG+ plasmids, derived from matings between Hfr AB312 and a recA recipient, have been shown to have deletions of at least 50% of the F genome, including the region in which the tra genes map.
Clark, Alvin J. +2 more
core +1 more source
Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Congcong Tian, Haiyun Gan
wiley +1 more source
DNA Synthesis, Methylation and Degradation During Conjugation in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]
, 1985 We have investigated the timing of DNA synthesis, methylation and degradation during macronuclear development in the ciliate, Tetrahymena thermophila. DNA synthesis was first detected in the anlagen early in macronuclear development, but the majority of ...
Harrison, Gail Singer +1 more
core +1 more source
Heritable genome editing in C. elegans via a CRISPR-Cas9 system [PDF]
, 2014 CRISPR-Cas systems have been used with single-guide RNAs for accurate gene disruption and conversion in multiple biological systems. Here we report the use of the endonuclease Cas9 to target genomic sequences in the C.
Calarco, John A. +5 more
core +1 more source