Results 61 to 70 of about 2,871 (153)

Cancer Being Extra: Extrachromosomal DNA Promotes Heterogeneity and Resistance in Cancer [PDF]

, 2022
In cancer, oncogenes are frequently amplified on extrachromosomal DNA (ecDNA), circular acentric DNA fragments ranging from hundreds of kilobases to multiple megabases.
Lange, Joshua
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Plasmid Copy Number Variation Impacts Pathogenicity and Quantification of Curtobacterium flaccumfaciens pv. flaccumfaciens Infecting Mung Bean

Plant Pathology, Volume 74, Issue 9, Page 2670-2681, December 2025.
Dynamic plasmid copy numbers in the bacterial pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens influence disease expression in mung beans. ABSTRACT In bacteria, plasmids can confer the ability to cause disease. Although they can potentially vary in copy number, little has been reported on the dynamics of plasmids in plant‐pathogenic bacteria ...
Ahmed Saad, Niloofar Vaghefi, Barsha Poudel, Anthony J. Young, Lisa A. Kelly, Noel L. Knight   +5 more
wiley   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, Volume 19, Issue 11, Page 2999-3002, November 2025.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Extrachromosomal DNA d relieving heredity constraints, accelerating tumour evolution [PDF]

, 2020
Oncogene amplification on extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells can rapidly adapt to changes in the tumour microenvironment.
Swanton, C, Shoura, MJ, Mischel, PS, Bailey, C   +3 more
core  

Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression

, 2023
Extrachromosomal circular DNAs (eccDNAs) carrying random genomic segments are broadly found across different cancer types, but their molecular functions and impact in gastric cancer (GC) are rarely known.
Peng Han, Xi Xiang, Li, Wenchao, Xianming Jiang, Ying Zhang, Li, Jing, Han, Peng, Wenchao Li, Jiaying Yu, Pan, Xiaoguang, Lv, Wei, He, Yulong, Jiang, Xianming, Xiaoguang Pan, Jing Li, Zhang, Haoran, Zhang, Ying, Yulong He, Haoran Zhang, Wei Lv, Xiang, Xi, Yu, Jiaying   +21 more
core   +1 more source

Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Yanfei Cheng, Yuanyuan Shi, Ning Sun, Xin Zhang, Mengwei Sun, Xiuping He   +5 more
wiley   +1 more source

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, Volume 24, Issue 8, August 2025.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Maintenance and inheritance of yeast prions

, 1996
The unusual genetic behaviour of two yeast extrachromosomal elements [PSI] and [URE3] is entirely consistent with a prion-like mechanism of inheritance involving an autocatalytic alteration in the conformation of a normal cellular protein. In the case of
Tuite, Mick F., Lindquist, Susan L.
core   +1 more source

Evolution of mitochondria and plastids across populations of a keystone marine plant Zostera marina [PDF]

, 2023
The genomes of mitochondria and plastids are testimony to their evolutionary origin as bacterial endosymbionts during the emergence of eukaryotic cells. The two organellar genomes differ markedly from the nuclear genome and between each another. They are
Khachaturyan, Marina
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