Results 41 to 50 of about 208,533 (137)

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

Nature Communications
Borgs are huge extrachromosomal elements (ECE) of anaerobic methane-consuming “Candidatus Methanoperedens” archaea. Here, we used nanopore sequencing to validate published complete genomes curated from short reads and to reconstruct new genomes.
Marie C. Schoelmerich, Lynn Ly, Jacob West-Roberts, Ling-Dong Shi, Cong Shen, Nikhil S. Malvankar, Najwa Taib, Simonetta Gribaldo, Ben J. Woodcroft, Christopher W. Schadt, Basem Al-Shayeb, Xiaoguang Dai, Christopher Mozsary, Scott Hickey, Christine He, John Beaulaurier, Sissel Juul, Rohan Sachdeva, Jillian F. Banfield   +18 more
doaj   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome

New Phytologist, Volume 249, Issue 5, Page 2215-2223, March 2026.
Summary Adaptations that enable plant‐associated bacteria to fill disparate niches comprise a critical component of microbial diversity. Genes that confer locally adaptive bacterial traits, ranging from heavy metal resistance to pathogen or symbiont infectivity, often reside within mobile genetic elements (MGEs) that can move between genomes.
Stephanie Porter, Dominique Holtappels, Angeliqua Montoya, Britt Koskella   +3 more
wiley   +1 more source

Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos, Francesc Padrós, Maria Constenla, Ana Jerončić, Dimitra Kogiannou, Sofia Consuegra, Mikolaj Adamek, Ivona Mladineo   +7 more
wiley   +1 more source

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

Plasmid Copy Number Variation Impacts Pathogenicity and Quantification of Curtobacterium flaccumfaciens pv. flaccumfaciens Infecting Mung Bean

Plant Pathology, Volume 74, Issue 9, Page 2670-2681, December 2025.
Dynamic plasmid copy numbers in the bacterial pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens influence disease expression in mung beans. ABSTRACT In bacteria, plasmids can confer the ability to cause disease. Although they can potentially vary in copy number, little has been reported on the dynamics of plasmids in plant‐pathogenic bacteria ...
Ahmed Saad, Niloofar Vaghefi, Barsha Poudel, Anthony J. Young, Lisa A. Kelly, Noel L. Knight   +5 more
wiley   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, Volume 19, Issue 11, Page 2999-3002, November 2025.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer

Molecular Cancer
Darwinian clonal evolution provides a necessary framework for understanding tumour progression, yet emerging evidence shows that some cancers depart from a strictly gradualist tempo through episodic "macroevolutionary" leaps.
Laurine Lagache, Julien Salzet, Isabelle Fournier, Michel Salzet   +3 more
doaj   +1 more source

Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Yanfei Cheng, Yuanyuan Shi, Ning Sun, Xin Zhang, Mengwei Sun, Xiuping He   +5 more
wiley   +1 more source

DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA‐positive tumours

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Congcong Tian, Haiyun Gan
wiley   +1 more source