Results 41 to 50 of about 2,871 (153)

Yersinia pestis pathogenicity

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Yersinia pestis belongs to those pathogenic bacteria which produce lipopolysaccharide (LPS) having the function of a toxin. In order to make a toxic effect the polymer must be separated from the cell outer membrane and presented to the immunocompetent ...
V. I. Tynyanova, E. P. Sokolova, V. P. Zyuzina, G. V. Demidova   +3 more
doaj   +1 more source

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

, 2023
ABSTRACT The chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes on different chromosomes assort independently, providing a fundamental tenet of Mendelian inheritance.
King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Joshua T. Lange, Jens Luebeck, Elisa Scanu, Britney Jiayu He, Lotte Brückner, Rui Li, Rocío Chamorro González, Rachel Schmargon, Jan R. Dörr, Julia A. Belk, Vineet Bafna, Benjamin Werner, Weini Huang, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang   +18 more
openaire   +2 more sources

EXTRACHROMOSOMAL INHERITANCE OF CARBON DIOXIDE SENSITIVITY IN THE MOSQUITO CULEX QUINQUEFASCIATUS [PDF]

Genetics, 1983
ABSTRACT Mosquitoes from a laboratory colony of Culex quinquefasciatus from Matsu Island, China, develop irreversible paralytic symptoms after exposure to carbon dioxide at 1°. This CO2 sensitivity is caused by an inherited infectious agent, probably a virus.
D A, Shroyer, L, Rosen
openaire   +2 more sources

Extrachromosomal DNA in HPV mediated oropharyngeal cancer drives diverse oncogene transcription [PDF]

, 2021
PURPOSE: Human papillomavirus (HPV) plays a major role in oncogenesis and circular extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship between HPV and circular ecDNA in human cancer is not understood.
Mischel, Paul S, Luebeck, Jens, Ball, Laurel, Califano, Joseph, Flagg, Mitchell, Pang, John, Panuganti, Bharat, Mischel, Paul S., Bafna, Vineet, Guo, Theresa, Xu, Guorong, Finegersh, Andrey, Cahill, Gabrielle, Nguyen, Nam, Fisch, Kathleen, Nakagawa, Takuya, Ren, Shuling, Sadat, Sayed   +17 more
core   +1 more source

A genetic study of a Staphylococus aureus plasmid involving cure and transference

São Paulo Medical Journal
High frequency transfer and elimination of drug resistance may indicate an extrachromosomal inheritance of genetic determinants. This study shows the cure and transfer of a small plasmid and tetracycline resistance in Staphylococcus aureus 1030 (55)TetR ...
Ana Lúcia Costa Darini
doaj   +1 more source

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

eLife
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna   +6 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer.

, 2021
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models and ...
Kim, Hoon, Yu, Qianru, Das, Sunit, Gujar, Amit D, Johnson, Kevin C., Jillette, Nathaniel, Verhaak, Roel G W, Costa, Megan L., Guthrie, Molly, Cheng, Albert W., Amin, Samirkumar B., Johnson, Kevin C, Amin, Samirkumar B, Clow, Patricia A, Costa, Megan L, Gujar, Amit D., Yi, Eunhee, Zhao, Dacheng, Jillette, Nathaniel L, Clow, Patricia A., Verhaak, Roel GW, Cheng, Albert W   +21 more
core   +1 more source

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host

, 2005
The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner.
Henriquez, F L, Muench, S P, Kirisits, M J, Rice, DW, Prigge, ST, Henriquez, FL, Ferguson, DJ, Ferguson, D J P, Rice, D W, Roberts, C W, McLeod, R L, McLeod, RL, Ferguson, David, Kirisits, MJ, Prigge, S T, Muench, SP, Roberts, CW   +16 more
core   +1 more source

AmpliconClassifier version 0.4.14 classification of TCGA results from Kim, et al., 2020

, 2023
The results are reported in "Coordinated inheritance of extrachromosomal DNA species in human cancer cells - PMC (nih.gov)"
Jens Luebeck (8346651), King L. Hung (15117769)   +1 more
core   +1 more source