Multiomics Research Strategies in Cancer: A Growing and Innovative Field
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du +8 more
wiley +1 more source
Body Perception: Intersensory Origins of Self and Other Perception in Newborns [PDF]
SummarySelf-perception involves integrating changes in visual, tactile, and proprioceptive stimulation from self-motion and discriminating these changes from those of other objects.
Bahrick, L.E.
core +3 more sources
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma [PDF]
ABSTRACT To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them.
Ana C. deCarvalho +18 more
openaire +3 more sources
Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome
Summary Adaptations that enable plant‐associated bacteria to fill disparate niches comprise a critical component of microbial diversity. Genes that confer locally adaptive bacterial traits, ranging from heavy metal resistance to pathogen or symbiont infectivity, often reside within mobile genetic elements (MGEs) that can move between genomes.
Stephanie Porter +3 more
wiley +1 more source
Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture
The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos +7 more
wiley +1 more source
CURRENT OPINION ON TAXONOMY, MORPHOLOGICAL, AND FUNCTIONAL PROPERTIES OF BIFIDOBACTERIA
Here we present current information on the taxonomy of bifidobacteria, which is based on their phenotypic, genetic and phylogenetic characteristics.
YULIYА V. Zakharova +1 more
doaj
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun +7 more
wiley +1 more source
Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core +1 more source
Dynamic plasmid copy numbers in the bacterial pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens influence disease expression in mung beans. ABSTRACT In bacteria, plasmids can confer the ability to cause disease. Although they can potentially vary in copy number, little has been reported on the dynamics of plasmids in plant‐pathogenic bacteria ...
Ahmed Saad +5 more
wiley +1 more source
Extensive horizontal gene transfer in cheese-associated bacteria. [PDF]
Acquisition of genes through horizontal gene transfer (HGT) allows microbes to rapidly gain new capabilities and adapt to new or changing environments.
Bonham, Kevin S +2 more
core +3 more sources

