Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer [PDF]
Molecular CancerExtrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification.
Bi-xia Liu +13 more
doaj +2 more sources
Extrachromosomal circular DNA are functional, heritable units that expand genomic plasticity and confer resilience [PDF]
Frontiers in Plant ScienceAlthough far less well-known and understood than chromosomal DNA, extrachromosomal circular DNA (eccDNA) are a pervasive and dynamic component of eukaryotic genomes.
Dana R. MacGregor, Christopher A. Saski
doaj +2 more sources
Coordinated inheritance of extrachromosomal DNAs in cancer cells [PDF]
NatureAbstractThe chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell ...
King L. Hung +24 more
openaire +3 more sources
What we learn from weed genetics. [PDF]
Am J BotAmerican Journal of Botany, Volume 113, Issue 4, April 2026.
VanWallendael A.
europepmc +2 more sources
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma [PDF]
Nature Genetics, 2016 ABSTRACT To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them.
Ana C. deCarvalho +18 more
openaire +4 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles. [PDF]
FEBS LettExtrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Casey D, Gao Z, Boyes J.
europepmc +2 more sources
Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer [PDF]
Molecular CancerDarwinian clonal evolution provides a necessary framework for understanding tumour progression, yet emerging evidence shows that some cancers depart from a strictly gradualist tempo through episodic "macroevolutionary" leaps.
Laurine Lagache +3 more
doaj +2 more sources
Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution [PDF]
Abstract Gene amplification in the form of extrachromosomal DNA (ecDNA) is a frequent driver in multiple cancer types. As ecDNA lack centromeres, their mitotic segregation does not follow traditional inheritance principles. However, the mechanisms that govern ecDNA fate following mitosis remain unclear.
Shir Marom +24 more
openaire +2 more sources
An empirical investigation of inheritance trends in JAVA OSS evolution [PDF]
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Inheritance is a salient feature of Object-Oriented (OO) paradigm which facilitates reuse and improves system comprehensibility in OO systems.
Nasseri, Emal
core +7 more sources
Wealth, families and death: socio-legal perspectives on wills and inheritance: introduction [PDF]
, 2014 Inheritance as both a concept and a practice is of deep significance within all societies and jurisdictions. Located at the intersection between economics, family relations and the end of life, it offers a unique perspective on a variety of contemporary ...
Monk, Daniel, Hacker, D.
core +7 more sources