Extrachromosomal elements in a super-suppression system of yeast I. A nuclear gene controlling the inheritance of the extrachromosomal elements [PDF]
Heredity, 1971 Extrachromosomal elements in a super-suppression system of yeast I.
B S Cox
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Extrachromosomal circular DNA are functional, heritable units that expand genomic plasticity and confer resilience [PDF]
Frontiers in Plant ScienceAlthough far less well-known and understood than chromosomal DNA, extrachromosomal circular DNA (eccDNA) are a pervasive and dynamic component of eukaryotic genomes.
Dana R. MacGregor, Christopher A. Saski
doaj +2 more sources
What we learn from weed genetics. [PDF]
Am J BotAmerican Journal of Botany, Volume 113, Issue 4, April 2026.
VanWallendael A.
europepmc +2 more sources
Extrachromosomal inheritance of oligomycin resistance in yeast
FEBS Letters, 1970 Norio Gunge
exaly +4 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles. [PDF]
FEBS LettExtrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Casey D, Gao Z, Boyes J.
europepmc +2 more sources
Sperm-Mediated Transgenerational Inheritance
Frontiers in Microbiology, 2017 Spermatozoa of virtually all species can spontaneously take up exogenous DNA or RNA molecules and internalize them into nuclei. In this article I review evidence for a key role of a reverse transcriptase (RT) activity, encoded by LINE-1 retrotransposons,
Corrado Spadafora
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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma [PDF]
Nature Genetics, 2016 ABSTRACT To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them.
Ana C. deCarvalho +18 more
openaire +4 more sources
EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA [PDF]
iScience, 2019 Summary: Oncogene amplification is one of the most common drivers of genetic events in cancer, potently promoting tumor development, growth, and progression.
Utkrisht Rajkumar +6 more
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Coordinated inheritance of extrachromosomal DNAs in cancer cells [PDF]
NatureAbstractThe chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell ...
King L. Hung +24 more
openaire +3 more sources
Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment. [PDF]
Cancer InnovExtrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Li H, Cai J, Zhao G, Zou L.
europepmc +2 more sources