Results 131 to 140 of about 5,246,646 (349)

Trends in sexually transmitted infections in general practice 1990-2000: population based study using data from the UK general practice research database [PDF]

, 2006
Objective: To describe the contribution of primary care to the diagnosis and management of sexually transmitted infections in the United Kingdom, 1990-2000, in the context of increasing incidence of infections in genitourinary medicine clinics ...
Brook, M.G., Cassell, J.A., Hayward, A.C., Hughes, G., Islam, A., Johnson, A.M., Kinghorn, G.R., Majeed, A., Mercer, C.H., Petersen, I., Ross, J.D., Simms, I., Stephenson, J.M., Sutcliffe, L.   +13 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science
Intestinal fistula is a serious condition characterized by abnormal connections between the intestine and surrounding tissues. Despite advances in comprehensive management of intestinal fistulas, patients often need to undergo definitive surgery and face
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Preventability and Causes of Readmissions in a National Cohort of General Medicine Patients.

JAMA Internal Medicine, 2016
Andrew D. Auerbach, S. Kripalani, E. Vasilevskis, N. Sehgal, Peter K. Lindenauer, J. Metlay, Grant S. Fletcher, G. Ruhnke, S. Flanders, Christopher S Kim, Mark V. Williams, L. Thomas, V. Giang, S. Herzig, Kanan Patel, W. Boscardin, Edmondo Robinson, J. Schnipper   +17 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

Advanced Science
Chordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive, leading to a lack of effective therapeutic targets and drug sensitivity ...
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
doaj   +1 more source

Functional evaluation of hepatic parenchyma with dynamic tests (Indocyanine green and Hippurate ratio) in patients with HCC [PDF]

, 2011
Our aim was to assess hepatic functionality in patients with HCC and candidate for liver resection. We used dynamic tests of liver functionality Indocyanine green (ICG) and Hippurate ratio, for the evaluation of surgical risk and postoperative clinical
PETRACCIA, LUISA
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock

Critical Care Medicine, 2017
A. Davis, J. Carcillo, R. Aneja, A. Deymann, John C. Lin, Trung C. Nguyen, R. Okhuysen-Cawley, Monica S Relvas, R. Rozenfeld, P. Skippen, Bonnie J Stojadinovic, E. Williams, T. Yeh, F. Balamuth, J. Brierley, A. D. De Caen, I. Cheifetz, K. Choong, E. Conway, Timothy T. Cornell, A. Doctor, M. Dugas, J. Feldman, J. Fitzgerald, H. Flori, J. Fortenberry, A. L. Graciano, B. Greenwald, M. Hall, Y. Han, L. Hernan, J. Irazuzta, E. Iselin, É. W. van der Jagt, H. Jeffries, S. Kache, C. Katyal, N. Kissoon, A. Kon, Martha C. Kutko, G. MacLaren, T. Maul, R. Mehta, F. Odetola, Kristine A. Parbuoni, Raina M. Paul, M. Peters, S. Ranjit, K. Reuter-Rice, E. Schnitzler, Halden F. Scott, A. Torres, Jacki Weingarten-Abrams, S. Weiss, J. Zimmerman, A. Zuckerberg   +55 more
semanticscholar   +1 more source