Results 131 to 140 of about 1,803,537 (266)

Arabic version of the General Sleep Disturbance Scale among healthcare night-shift workers: a cross-sectional validation study. [PDF]

BMJ Neurol Open
Osama W, Magdy R, Elashiry A, Hussein M, Tarek MA, Abdelbar SMM, Ismail SAA, Mourad BH, Hegazy MT, Farrag A, Abdel-Hamid HM, Heneidy S.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

First-Line Tislelizumab Combined with Bevacizumab and CAPOX for Metastatic Gastroesophageal Adenocarcinoma with Low Programmed Death-Ligand 1 Expression

Cancer Communications
Ru Jia, Yan-Rong Wang, Fang-Fang Liu, Yue Ma, Hai-Yan Si, Lu Han, Miao-Miao Gou, Zhao-Li Tan, Nan Zhang, Guo-Chao Deng, Meng-Jiao Fan, Yue Shi, Yao-Yue Zhang, Yu-Shan Jia, Jun-Nan Xu, Xiao-Xing Su, Quan-Li Han, Zhi-Kuan Wang, Guang-Hai Dai   +18 more
doaj   +1 more source

Ethnic differences in specialty destinations in UK medicine: a repeated cross-sectional analysis of secondary data. [PDF]

J R Soc Med
Brown C, Morrison N, Aus K, Coulson A, Sam AH.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Breast cancer screening in Europe and the role of general practitioners: A 32-country comparative survey. [PDF]

Eur J Gen Pract
Papageorgiou DI, Smyrnakis E, Harris M, Skuja I, Adžić ZO, Apostolova G, Bensemmane S, Brekke M, Buczkowski K, Buono N, Burgers J, Danilenko J, Högberg C, Kafadar D, Koskela T, Kral N, Kraxner R, Küppers L, Legoff D, Marzo-Castillejo M, Pless A, Ponzel N, Puia A, Radzevičienė-Jurgutė R, Redmond P, Särgava K, Šter MP, Sulashvili M, Vedsted P, Wöstmann X, Zafirovska M, Zaidan R, Hoffman R.   +32 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Evaluation of hand functional indices in association to clinical, laboratory, and radiologic data in patients with systemic sclerosis. [PDF]

Turk J Phys Med Rehabil
Yetişir A, Varkal G, Deniz V, Sariyildiz A, Türk İ.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source