Results 61 to 70 of about 214,705 (260)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Economics and CultureThis study explores whether R programming can transform unstructured qualitative social media data into a quantitative format suitable for econometric modelling. It specifically examines how elements such as text, emojis, and sentiment from Reddit and X (
Litvinenko Alexey +2 more
doaj +1 more source
The potential of STEM-based curriculum in realizing 21st-century learning: Bibliometric analysis
Inovasi KurikulumEducation, in general, cannot be separated from various existing problems. One of these problems is a gap between graduate education and industry needs. This causes multidisciplinary learning, such as STEM, to be carried out.
Wahyudin Wahyudin +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Computer Adaptive Testing Simulations in R
International Journal of Assessment Tools in Education, 2019 Computer adaptive testing is an important research field in educationalmeasurement, and simulation studies play a critically important role in CATdevelopment and evaluation.
Basak Erdem Kara
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Development of algorithms and software for classification of nucleotide sequences
Informatika, 2019 Coding and non-coding nucleotide sequences of the human reference genome have been investigated. Seven models of vectorization of nucleotide sequences based on mono-, bi-, trigram nucleotide frequencies, parameters of the category-position-frequency ...
V. R. Zakirava +4 more
doaj
R-algorithm for Solving Quadratic Programming Problems
Кібернетика та комп'ютерні технологіїQuadratic programming problems have a wide range of practical applications in various fields of science and engineering, particularly in financial modeling and pattern recognition, which underscores the relevance of studying methods for their efficient ...
Petro Stetsyuk +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source