Results 81 to 90 of about 19,195,534 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modeling and solving linear programming with R [PDF]

, 2015
Linear programming is one of the most extensively used techniques in the toolbox of quantitative methods of optimization. One of the reasons of the popularity of linear programming is that it allows to model a large variety of situations with a simple ...
Sallán Leyes, José María, Lordan González, Oriol, Fernández Alarcón, Vicenç   +2 more
core   +1 more source

The Technological Bridge: R Programming’s Utility in Converting Social Media Data for Quantitative Financial Analysis

Economics and Culture
This study explores whether R programming can transform unstructured qualitative social media data into a quantitative format suitable for econometric modelling. It specifically examines how elements such as text, emojis, and sentiment from Reddit and X (
Litvinenko Alexey, Samuli Saarinen, Litvinenko Anna   +2 more
doaj   +1 more source

The potential of STEM-based curriculum in realizing 21st-century learning: Bibliometric analysis

Inovasi Kurikulum
Education, in general, cannot be separated from various existing problems. One of these problems is a gap between graduate education and industry needs. This causes multidisciplinary learning, such as STEM, to be carried out.
Wahyudin Wahyudin, Muhammad Rafi Valliansyah, Cindy Sri Meidina Adeliani, Muhammad Bahrul Ulum   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Software Carpentry: Programming with R

, 2016
<p>A full-day lesson on programming with R, written and maintained by the Software Carpentry community.</p ...
Stevens, Sarah, Reid, Joey (8167146), Banaszkiewicz, Piotr, Sumner, Michael, Philibert, Raissa, Nakhoul, Hani, Boughton, Andy (8167017), Ranjard, Louis (8167143), Cabunoc Mayes, Abigail (8167026), Blischak, John, Weber, Lukas, Levy, Michael (5397629), Stachelek, Joseph, Bekolay, Trevor (8167008), Gray, Jeremy (8167068), Andrea, Paula, Foos, Marianna, Bruger, Eric, Turek, Daniel (8167191), Martinez, Carlos, Nakhoul, Hani (8167125), Srinivasan, Karthik, Turek, Daniel, Broman, Karl (8167020), Hiebert, James (8167089), Michonneau, François (6793397), Mills, Bill (8167119), Ritchie, Scott, Philibert, Raissa (8167137), Arnold, Jeffrey (8166990), Andrea, Paula (8166987), Guzman, Melissa (8167074), Bajcz, Alex (8166993), Wright, Tom, Jackson, Mike (5303389), Bajcz, Alex, Mills, Bill, Pipitone, Jon (8167140), Schmiedeskamp, Peter (8167161), Dickenson, Matt (8167035), Bass, Greg (8167005), Gray, Jeremy, Emonet, Rémi (8167044), Haine, Denis (8167077), Pennekamp, Frank (8167134), Robinson, Natalie (8167152), Ainsley, Joshua, Teucher, Andy (8167188), Ranjard, Louis, Chamberlain, Scott (5229899), Bass, Greg, Guo, Jessica, Henderson, Donna (8167083), Hiebert, James, Teucher, Andy, Fournier, Auriel (8167053), Woo, Kara (8167203), O'Leary, Aaron, Boughton, Andy, Michonneau, François, Pennekamp, Frank, Poisot, Timothée (5302039), King, W. Trevor (8167104), Chamberlain, Scott, Bruger, Eric (8167023), Allen, James (6193286), Silva, Raniere, Henderson, Donna, Banaszkiewicz, Piotr (8166996), Black, Mik (8167011), Levy, Michael, Woo, Kara, Mandel, Mark, Silva, Raniere (5285224), Milliman, Eric (8167116), Bekolay, Trevor, Marwick, Ben, Simpson, Gavin, Gibling, Heather (8167065), Alsheikh-Hussain, Areej (8166984), Duckles, Jonah, Arnold, Jeffrey, Dickenson, Matt, Duckles, Jonah (8167041), Supp, Sarah (8167185), Zimmerman, Naupaka, Ghaffari, Noushin (8167062), Chen, Daniel (8167029), O'Leary, Aaron (8167131), Ritchie, Scott (8167149), Held, Fabian, Marwick, Ben (5254174), Broman, Karl, Black, Mik, Fournier, Auriel, Wilson, Greg, García-Algarra, Javier, Pipitone, Jon, Barneche, Diego (8167002), Sumner, Michael (8167182), Jacobson, Elsie (8167095), Emonet, Rémi, Held, Fabian (8167080), Signal, Beth, Ghaffari, Noushin, Alsheikh-Hussain, Areej, Foos, Marianna (8167047), Mickley, James, Aiello-Lammens, Matthew, Staneva, Valentina (8167176), Cabunoc Mayes, Abigail, Supp, Sarah, Moris, Joaquin (8167122), Jacobson, Elsie, Poisot, Timothée, Turner, Stephen (5314226), Blischak, John (8167014), Fredman, David (8167056), Milliman, Eric, Sachs, Michael, Barneche, Diego, Hansen, Michael, Reid, Joey, King, W. Trevor, García-Algarra, Javier (8167059), Hollister, Jeff, Allen, James, Ainsley, Joshua (8166981), Ahmadia, Aron, Haine, Denis, Dashnow, Harriet, Stevens, Sarah (8167179), Moris, Joaquin, Guo, Jessica (8167071), Schmiedeskamp, Peter, Nilsson, Matthias, Schloss, Pat, Droop, Alastair, Wilson, Greg (8167200), Robinson, Natalie, Hollister, Jeff (8167092), Turner, Stephen, Dashnow, Harriet (8167032), Weber, Lukas (8167194), Jackson, Mike, Sachs, Michael (8167155), Martinez, Carlos (8167110), Stachelek, Joseph (8167173), Gibling, Heather, Mandel, Mark (8167107), Fredman, David, Srinivasan, Karthik (8167170), Ahmadia, Aron (8166975), Hansen, Michael (5240518), Schloss, Pat (8167158), Wright, Tom (8167206), Simpson, Gavin (8167167), Guzman, Melissa, Staneva, Valentina, Aiello-Lammens, Matthew (8166978), Zimmerman, Naupaka (7259267), Mickley, James (8167113), Chen, Daniel, Signal, Beth (8167164), Droop, Alastair (8167038), Nilsson, Matthias (8167128)   +165 more
core   +1 more source

Computer Adaptive Testing Simulations in R

International Journal of Assessment Tools in Education, 2019
Computer adaptive testing is an important research field in educationalmeasurement, and simulation studies play a critically important role in CATdevelopment and evaluation.
Basak Erdem Kara
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Basic Statistical Programming in R

A draft guide book in basic statistics using R programming ...
Sherwin Balbuena (17933618)
core   +1 more source