Results 21 to 30 of about 1,048,448 (240)

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation

Frontiers in Immunology, 2023
IntroductionThe complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases.
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo   +14 more
doaj   +1 more source

Predictors of interest in predictive testing for rheumatoid arthritis among first degree relatives of rheumatoid arthritis patients [PDF]

, 2022
OBJECTIVES: There is increasing interest in prediction and prevention of rheumatoid arthritis (RA). It is important to understand the views of those at risk to inform the development of effective approaches.
Mallen
core   +1 more source

RA-induced meiosis-associated gene expression was attenuated by JNK inhibitor treatment.

, 2019
Control ovaries and testes at E13.5 and P2 were cultured in vitro and treated with 1 μM RA and/or 1 μM JNK inhibitor SP600125. The expression of meiotic genes was examined by immunofluorescence and real-time PCR.
Fei Gao (29262), Zhiheng Xu (1751443), Feng Han (10919), Yingying Qin (461118), Zi-Jiang Chen (130783), Ting Guo (210829), Hanni Ke (5624507), Axel Behrens (47682), Lianjun Zhang (181973), Yaqing Wang (5041202), Yaqiong Li (295868), Yang Zhou (65942), Min Chen (147733), Binyang Xu (5624504), Yan Qin (118276)   +14 more
core   +1 more source

Identification of microsatellite loci according to BAC sequencing data and their physical mapping to the bread wheat 5B chromosome

Вавиловский журнал генетики и селекции, 2016
The shortage of polymorphic markers for the regions of wheat chromosomes that encode commercially valuable traits determined the need for studying wheat microsatellite loci. In this work, SSR markers for individual regions in the short arm of bread wheat
M. A. Nesterov, D. A. Afonnikov, E. M. Sergeeva, L. A. Miroshnichenko, M. K. Bragina, A. O. Bragin, G. V. Vasiliev, E. A. Salina   +7 more
doaj   +1 more source

Peningkatkan Kemampuan Motorik Kasar Melalui Bermain Games Di Lapangan Pada Santri Ra Albanatu Sholiha Medan Labuhan [PDF]

, 2020
Penelitian ini bertujuan untuk meningkatkan kemampuan motorik kasar melalui bermain games di lapangan pada santri RA. Al-Banatu Sholiha Medan Labuhan. Penelitian dilakukan pada bulan Juli hingga September 2016.
Lubis, Latifa Anum; RA Nurul Aflah
core   +2 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke

BMC Medical Genetics, 2018
Background Despite the important role of the nerve growth factor in the survival and maintenance of neurons in ischemic stroke, data regarding the relationships between variations in the encoding gene and stroke are lacking.
Ani Stepanyan, Roksana Zakharyan, Arsen Simonyan, Gohar Tsakanova, Arsen Arakelyan   +4 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Concentration-dependent effects of bacterial melanin on new superoxide-producing associates in rat tissues: a rotenone neurotoxic model of parkinson’s disease

BMC Pharmacology and Toxicology
Background Oxidative stress plays a central role in the degeneration of dopaminergic neurons and is a key factor in the pathogenesis of Parkinson’s disease (PD). Therefore, antioxidant therapy represents a promising therapeutic strategy.
Margarita Danielyan, Kristine Karapetyan, Ruzan Simonyan, Gegham Simonyan, Madlena Babayan, Mikhail Poghosyan, Hasmik Yekmalyan, Maxim Simonyan, Karen Simonyan, Kristina Nebogova   +9 more
doaj   +1 more source