Results 1 to 10 of about 916,510 (294)

Development of an efficient method for obtaining lactose and lactulose from whey [PDF]

Pharmacia, 2023
Taking into account a wide range of lactulose application in pharmaceutics, baby food production and other fields, along with the importance of technological solutions for its extraction from milk whey, the presented work was carried out to obtain ...
Avetis Tsaturyan, Lilya Arstamyan, Anyuta Sargsyan, Jaklina Saribekyan, Ani Voskanyan, Ella Minasyan, Monika Israelyan, Tatevik Sargsyan, Lala Stepanyan   +8 more
doaj   +3 more sources

Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson’s disease

BMC Neuroscience, 2023
According to recent research, selective neuronal vulnerability in Parkinson’s disease (PD) results from several phenotypic traits, including calcium-dependent, feed-forward control of mitochondrial respiration leading to elevated reactive oxygen species ...
Margarita Danielyan, Kristina Nebogova, Ruzan Simonyan, Anichka Hovsepyan, Zubeida Avetisyan, Karen Simonyan, Gegham Simonyan, Vahagn Khachatryan, Kristine Karapetyan   +8 more
doaj   +1 more source

The Renaissance of Ras [PDF]

ACS Chemical Biology, 2014
Increased signaling by the small G protein Ras is found in many human cancers and is often caused by direct mutation of this protein. Hence, small-molecule attenuation of pathological Ras activity is of utmost interest in oncology. However, despite nearly three decades of intense drug discovery efforts, no clinically viable option for Ras inhibition ...
Milroy, L.G., Ottmann, C.
openaire   +3 more sources

Dynamic regulation of RAS and RAS signaling

Biochemical Journal, 2023
RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact with a wide range of effectors that control fundamental biochemical and biological processes. Emerging
Walter Kolch, Dénes Berta, Edina Rosta
openaire   +3 more sources

Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats

Biochemistry Research International, 2023
In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE)
Gayane Ghazaryan, Hasmik Zanginyan, Laura Hovsepyan, Artyom Azatyan, Maria Ghazaryan, Lusine Mardanyan   +5 more
doaj   +1 more source

An ayurvedic perspective along with in silico study of the drugs for the management of SARS-CoV-2

Journal of Ayurveda and Integrative Medicine, 2022
Background: COVID-19 is the disease caused by SARS-CoV2, it was identified in Wuhan, China, in 2019. It then extended across the globe and was termed as a pandemic in 2020.
Abhay Jayprakash Gandhi, Jalpa Deepak Rupareliya, V.J. Shukla, Shilpa B. Donga, Rabinarayan Acharya   +4 more
doaj   +1 more source

Predictive Value of Precision-Cut Lung Slices for the Susceptibility of Three Animal Species for SARS-CoV-2 and Validation in a Refined Hamster Model

Pathogens, 2021
In assessing species susceptibility for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and in the search for an appropriate animal model, multiple research groups around the world inoculated a broad range of animal species using various ...
Nora M. Gerhards, Jan B. W. J. Cornelissen, Lucien J. M. van Keulen, José Harders-Westerveen, Rianka Vloet, Bregtje Smid, Stéphanie Vastenhouw, Sophie van Oort, Renate W. Hakze-van der Honing, Jose L. Gonzales, Norbert Stockhofe-Zurwieden, Rineke de Jong, Wim H. M. van der Poel, Sandra Vreman, Jeroen Kortekaas, Paul J. Wichgers Schreur, Nadia Oreshkova   +16 more
doaj   +1 more source

Superoxide-producing thermostable associate from the small intestines of control and alloxan-induced diabetic rats: quantitative and qualitative changes

BMC Endocrine Disorders, 2022
Background: NADPH oxidase 1 (Nox1), which is highly expressed in the colon, is thought to play a potential role in host defense as a physical and innate immune barrier against commensal or pathogenic microbes in the gastrointestinal epithelium.
R. M. Simonyan, K. V. Simonyan, G. M. Simonyan, H. S. Khachatryan, M. A. Babayan, M. H. Danielyan, L. V. Darbinyan, M. A. Simonyan   +7 more
doaj   +1 more source

Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo [PDF]

Journal of Biological Chemistry, 1998
Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo.
M K, Jones, J H, Jackson
openaire   +2 more sources

Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2 [PDF]

Molecular and Cellular Biology, 2001
Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2. GRF2 is a widely expressed protein with several recognizable sequence motifs, including a Ras exchanger motif (REM), a PEST region containing a destruction box (DB), and a Cdc25 domain.
C L, de Hoog, J A, Koehler, M D, Goldstein, P, Taylor, D, Figeys, M F, Moran   +5 more
openaire   +2 more sources