Results 1 to 10 of about 211,660 (314)

Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes [PDF]

Cancer Informatics, 2017
The 3 human RAS genes play pivotal roles regulating proliferation, differentiation, and survival in normal cells and become mutated in 15% to 20% of all human tumors and amplified in many others.
Robert M Stephens, Ming Yi, Bailey Kessing, Dwight V Nissley, Frank McCormick   +4 more
doaj   +6 more sources

In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.

PLoS ONE, 2014
It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level T-cell ...
Stephen J Lynch, Jiri Zavadil, Angel Pellicer   +2 more
doaj   +2 more sources

K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer [PDF]

Vojnosanitetski Pregled, 2009
Beckground/Aim. K-ras oncogene is mutated in about 20% of lung cancer. The purpose of this study was to investigate the predictive significance for therapeutic response of K-ras mutations in advanced non-small cell lung cancer (NSCLC) patients.
Cvetković Gordana, Plavec Goran, Tomić Ilija, Ilić Vesna, Magić Zvonko, Tatomirović Željka, Novković Dobrivoje, Milić Rade, Karličić Vukojica   +8 more
doaj   +1 more source

Identification, classification and expression analysis of the Ras superfamily genes in the Pacific white shrimp, Litopenaeus vannamei

Frontiers in Marine Science, 2023
The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial
Shuqing Si, Shuqing Si, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Jianbo Yuan, Jianbo Yuan, Jianbo Yuan, Xiaoxi Zhang, Xiaoxi Zhang, Xiaoxi Zhang, Yang Yu, Yang Yu, Yang Yu, Song Yang, Fuhua Li, Fuhua Li, Fuhua Li   +18 more
doaj   +1 more source

Mutations of RAS genes identified in acute myeloid leukemia affect glycerophospholipid metabolism pathway

Frontiers in Oncology, 2023
BackgroundAcute myeloid leukemia (AML) is a malignant disease originating from myeloid hematopoietic stem cells. Recent studies have shown that certain gene mutations promote tumor cell survival and affect the prognosis of patients by affecting metabolic
Tianqi Liang, Yanxiang Kong, Hongman Xue, Wenqing Wang, Chunmou Li, Chun Chen   +5 more
doaj   +1 more source

Genome-Wide Identification of Immune-Related Alternative Splicing and Splicing Regulators Involved in Abdominal Aortic Aneurysm

Frontiers in Genetics, 2022
The molecular mechanism of AAA formation is still poorly understood and has not been fully elucidated. The study was designed to identify the immune-related genes, immune-RAS in AAA using bioinformatics methods.
Shiyong Wu, Shibiao Liu, Ningheng Chen, Chuang Zhang, Hairong Zhang, Xueli Guo   +5 more
doaj   +1 more source

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. [PDF]

PLoS ONE, 2012
Certain oncolytic viruses exploit activated Ras signaling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-
Sherri L Christian, Dong Zu, Maria Licursi, Yumiko Komatsu, Theerawat Pongnopparat, Dianne A Codner, Kensuke Hirasawa   +6 more
doaj   +1 more source

RASopathies and cardiac manifestations

Frontiers in Cardiovascular Medicine, 2023
As binary switches, RAS proteins switch to an ON/OFF state during signaling and are on a leash under normal conditions. However, in RAS-related diseases such as cancer and RASopathies, mutations in the genes that regulate RAS signaling or the RAS itself ...
Nazia Hilal, Nazia Hilal, Nazia Hilal, Zi Chen, Zi Chen, Ming Hui Chen, Ming Hui Chen, Sangita Choudhury, Sangita Choudhury, Sangita Choudhury   +9 more
doaj   +1 more source

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable [PDF]

, 2003
In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed ...
Patek, C. E., Ann-Marie Ritchie, Melton, D. W., Doig, Jennifer, Arends, Mark J, D James Williamson, Charles E Patek, Arends, M. J., Ritchie, A. M., Plowman, Sarah J, Williamson, D James, Maureen J O'sullivan, Ritchie, Ann-Marie, Melton, David W, Sarah J Plowman, Hooper, Martin L, David W Melton, Harrison, David J, Arends, Mark J; id_orcid, O'Sullivan, M. J., Harrison, D. J., Hooper, M. L., Plowman, S. J., David J Harrison, O'Sullivan, Maureen J, Jennifer Doig, Doig, J., Martin L Hooper, Patek, Charles E, Mark J Arends, Williamson, D. J.   +30 more
core   +1 more source

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source