Results 21 to 30 of about 211,660 (314)
n-ras and k-ras Mutations Among Some Iraqi Patients with Acute Lymphoblastic Leukemia
Kufa Journal for Veterinary Medical Sciences, 2016 Somatic mutations which influence the activity of RAS genes, n-, h-, and k-ras, are recognized mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers.
Wiaam Ahmed Al-Amili +3 more
doaj +1 more source
A Novel Ras--Related Signature Improves Prognostic Capacity in Oesophageal Squamous Cell Carcinoma
Frontiers in Genetics, 2022 Oesophageal squamous cell carcinoma (ESCC) remains a clinically challenging disease with high morbidity rates and poor prognosis. ESCC is also the most common pathological type of oesophageal cancer (EC) in China.
Hao-Shuai Yang +7 more
doaj +1 more source
On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]
, 2004 Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
core +1 more source
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) is a major worldwide public health problem. The increase in the number of patients with CKD and end-stage kidney disease requesting renal dialysis or transplantation will progress to epidemic proportions in the next several ...
Yan-Ni Wang +9 more
doaj +1 more source
A catalogue of validated single nucleotide polymorphisms in bovine orthologs of mammalian imprinted genes and associations with beef production traits [PDF]
, 2010 peer-reviewedGenetic (or ‘genomic’) imprinting, a feature of approximately 100 mammalian genes, results in monoallelic expression from one of the two parentally inherited chromosomes. To date, most studies have been directed on imprinted genes in murine
Magee, David A +23 more
core +1 more source
Clinical and Translational Radiation Oncology, 2023 Approximately 60% of cancer patients receive curative or palliative radiation. Despite the significant role of radiotherapy (RT) as a curative approach for many solid tumors, tumor recurrence occurs, partially because of intrinsic radioresistance ...
Mahmoud Toulany
doaj +1 more source
ras gene Amplification and malignant transformation. [PDF]
Molecular and Cellular Biology, 1985 Morphologic transformation of NIH 3T3 mouse cells occurs upon transfection of these cells with large amounts (greater than or equal to 10 micrograms) of recombinant DNA molecules carrying the normal human H-ras-1 proto-oncogene. We provide experimental evidence indicating that transformation of these NIH 3T3 cells results from the combined effect of ...
Pulciani S. +4 more
openaire +4 more sources
, 2009 Surprisingly different frequencies and patterns of K-ras mutations are observed in human adenocarcinomas of the pancreas, colorectum and lung. Their respective relationships with smoking are apparently paradoxical. We evaluated all the available types of
Real, F.X. +15 more
core +1 more source
Biomolecules, 2020 RAS genes encode signaling proteins, which, in mammalian cells, act as molecular switches regulating critical cellular processes as proliferation, growth, differentiation, survival, motility, and metabolism in response to specific stimuli.
Renata Tisi +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source