An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma [PDF]
, 2016 The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced ...
Francke, S. +10 more
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TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas. [PDF]
, 2006 The putative role of TP53 and p16INK4A tumor suppressor genes and Ras oncogenes in the development and progression of salivary gland neoplasias was studied in 28 cases of pleomorphic adenomas (PA), 4 cases of cystic adenocarcinomas, and 1 case of ...
AGNESE, Valentina +18 more
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Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History [PDF]
, 2013 Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas.
Asano, Hiroaki +12 more
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PLoS ONE, 2020 Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable.
Seyhan Turk +11 more
doaj +1 more source
Understanding intellectual disability through RASopathies [PDF]
, 2014 Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the
Pagani, Mario Rafael +1 more
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Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. [PDF]
, 2018 BACKGROUND:Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such ...
Chen, Yibu +12 more
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Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes
Scientific Reports, 2018 In contrast to amniotes (reptiles, birds and mammals), anamniotes (fishes and amphibians) can effectively regenerate body appendages such as fins, limbs and tails. Why such a useful capability was progressively lost in amniotes remains unknown.
Anastasiya S. Ivanova +5 more
doaj +1 more source
n-ras and k-ras Mutations Among Some Iraqi Patients with Acute Lymphoblastic Leukemia
Kufa Journal for Veterinary Medical Sciences, 2016 Somatic mutations which influence the activity of RAS genes, n-, h-, and k-ras, are recognized mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers.
Wiaam Ahmed Al-Amili +3 more
doaj +1 more source
A Novel Ras--Related Signature Improves Prognostic Capacity in Oesophageal Squamous Cell Carcinoma
Frontiers in Genetics, 2022 Oesophageal squamous cell carcinoma (ESCC) remains a clinically challenging disease with high morbidity rates and poor prognosis. ESCC is also the most common pathological type of oesophageal cancer (EC) in China.
Hao-Shuai Yang +7 more
doaj +1 more source
Mutations and amplification of oncogenes in endometrial cancer [PDF]
, 1999 Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang +5 more
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