Results 31 to 40 of about 202,778 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Expression of ras-P21 and ras Gene Alteration in Pleomorphic Adenomas.

The Journal of Nihon University School of Dentistry, 1993
The expression of ras-P21 protein and gene alteration of the K-ras gene were examined in 12 cases of pleomorphic adenoma of the salivary gland. The tumor cells in all 12 cases were strongly stained for ras-P21 protein by the indirect immunoperoxidase method, suggesting the enhanced expression of ras-P21 protein in pleomorphic adenomas.
OKUTSUI, Seijiro, TAKEDA, Akio, SUZUKI, Tsubura, NAKAJIMA, Yoshitaka, SATO, Junichi, SUDA, Katsuyuki, FUKUDA, Masakatsu, USAMI, Tsutomu, HIMIYA, Takao, KUSAMA, Kaoru, KUDO, Itsuro, MORO, Itaru   +11 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

EXPRESIÓN DE LAS PROTEÍNAS p21 RAS y CÁNCER

Medicentro, 2011
Los genes ras pertenecen a una superfamilia de genes que codifican pequeñas proteínas de unión a nucleótidos de guanina. Las proteínas p21 Ras se localizan en la superficie interna de la membrana celular, donde actúan como interruptores moleculares ...
Otmara Guirado Blanco
doaj  

Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

BMC Cancer, 2009
Background Overexpression of Aurora-A and mutant Ras (RasV12) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not.
Huang Chi-Ying F, Lee Jenq-Chang, Tseng Ya-Shih, Liu Hsiao-Sheng   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ARTÍCULO DE RETRACTACIÓN: EXPRESIÓN DE LAS PROTEÍNAS P21 RAS Y CÁNCER. MEDICENTRO ELECTRÓN. 2007;11(1)

Medicentro, 2017
Los genes ras pertenecen a una superfamilia de genes que codifican pequeñas proteínas de unión a nucleótidos de guanina. Las proteínas p21 Ras se localizan en la superficie interna de la membrana celular, donde actúan como interruptores moleculares ...
Otmara Guirado Blanco, Eduard Escrich Escriche   +1 more
doaj  

Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.

PLoS Genetics, 2011
Cellular senescence involves epigenetic alteration, e.g. loss of H3K27me3 in Ink4a-Arf locus. Using mouse embryonic fibroblast (MEF), we here analyzed transcription and epigenetic alteration during Ras-induced senescence on genome-wide scale by chromatin
Atsushi Kaneda, Takanori Fujita, Motonobu Anai, Shogo Yamamoto, Genta Nagae, Masato Morikawa, Shingo Tsuji, Masanobu Oshima, Kohei Miyazono, Hiroyuki Aburatani   +9 more
doaj   +1 more source

Global gene analysis identifying genes commonly regulated by the Ras/Raf/MEK and type I IFN pathways

Genomics Data, 2015
Oncolytic viruses exploit alterations in cancer cells to specifically infect cancer cells but not normal healthy cells. Previous work has shown that oncogenic Ras interferes with interferon (IFN) signaling to promote viral replication.
Y. Komatsu, K. Hirasawa, S.L. Christian
doaj   +1 more source